Art

J-GLOBAL ID：202002235957507715   Reference number：20A0751692

Experimental analysis of the onset mechanism of TdP reported in an LQT3 patient during pharmacological treatment with serotonin-dopamine antagonists against insomnia and nocturnal delirium

不眠および夜間せん妄に対するセロトニン-ドーパミン拮抗薬による薬理学的治療中のLQT3患者において報告されたTdPの発症機序の実験的解析

Author (9)： Kambayashi Ryuichi (Department of Pharmacology, Faculty of Medicine, Toho University, Tokyo, Japan) ,  Hagiwara-Nagasawa Mihoko (Department of Pharmacology, Faculty of Medicine, Toho University, Tokyo, Japan) ,  Goto Ai (Department of Pharmacology, Faculty of Medicine, Toho University, Tokyo, Japan) ,  Chiba Koki (Department of Pharmacology, Faculty of Medicine, Toho University, Tokyo, Japan) ,  Izumi-Nakaseko Hiroko (Department of Pharmacology, Faculty of Medicine, Toho University, Tokyo, Japan) ,  Naito Atsuhiko T. (Division of Cellular Physiology, Department of Physiology, Faculty of Medicine, Toho University, Tokyo, Japan) ,  Matsumoto Akio (Department of Aging Pharmacology, Faculty of Medicine, Toho University, Tokyo, Japan) ,  Sugiyama Atsushi (Department of Pharmacology, Faculty of Medicine, Toho University, Tokyo, Japan) ,  Sugiyama Atsushi (Department of Aging Pharmacology, Faculty of Medicine, Toho University, Tokyo, Japan)
Material： Heart and Vessels (Web)
Volume： 35  Issue： 4  Page： 593-602  Publication year： 2020 
JST Material Number： U1589A  ISSN： 0910-8327  Document type： Article
Article type： 原著論文  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Thesaurus term： *antipsychotic agent ,...
Semi thesaurus term： Peripheral Vascular Resistance ,...

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Author keywords (5)： Perospirone ,  Blonanserin ,  LQT3 ,  J-T_peakc ,  Ca²⁺ overload

JST classification (2)： Basic research of psychotropic drugs  (GW03100Y) ,  Basic medicine on cardiovascular system  (GJ01020K)

Substance index (2)： Blonanserin ,  Perospirone hydrochloride

Terms in the title (10)： 不眠 ,  夜間せん妄 ,  セロトニン ,  ドーパミン拮抗薬 ,  薬理学的治療 ,  患者 ,  報告 ,  TDP ,  発症機序 ,  実験的解析