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J-GLOBAL ID：202002238153337632   Reference number：20A2681178

Effects of combined therapy of ACE inhibitor and exercise on the development of diabetic nephropathy in Otsuka Long-Evans Tokushima fatty rats

Otsuka Long-Evans Tokushima fattyラットにおける糖尿病性腎症発症に対するACE阻害薬と運動の併用療法の効果

Author (6)： Aoyama Shinichiro (Kokushikan University, School of Asia 21) ,  Shindo Daisuke (Laboratory of Health and Sports Science, Department of Pharmacy, Nihon University) ,  Otsuka Junichi (Department of Pharmacy, Jikei University Kashiwa Hospital) ,  Matsuo Eriko (College of Sports Sciences, Nihon University) ,  Matsubara Shigeru (College of Sports Sciences, Nihon University) ,  Suzuki Masato (Jikei University School of Medicine)
Material： Journal of Physical Fitness and Sports Medicine  (J Phys Fit Sports Med)
Volume： 9  Issue： 5  Page： 235-246(J-STAGE)  Publication year： 2020 
JST Material Number： L8465A  ISSN： 2186-8131  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： rat ,...
Semi thesaurus term： *ACE-inhibitor ,...

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Author keywords (5)： diabetic nephropathy ,  renal pentosidine ,  exercise ,  ACE inhibitor ,  glucose-lipid metabolism related parameters

JST classification (3)： Basic medicine on urogenital system  (GM01020T) ,  Metabolic diseases,nutritional diseases in general.  (GD05010J) ,  Basic therapeutics  (GC03012A)

Substance index (1)： Captopril

Reference (46)：

• 1) Suzuki M, Shindo D, Kimura M and Waki H. 2011. Effects of exercise, diet, and their combination on metabolic-syndrome-related parameters in OLETF rats. Int J Sport Nutr Exerc Metab 21: 222-232. doi: 10.1123/ijsnem.21.3.222.
• 2) The American College of Sports Medicine and the American Diabetes Association. 2010. Joint Position Statement. Exercise and type 2 diabetes. Med Sci Sports Exerc 42: 2282-2303. doi: 10.1249/MSS.0b013e3181eeb61c.
• 3) Julius S, Nesbitt SD, Egan BM, Weber MA, Michelson EL, Kaciroti N, Black HR, Grimm RH, Messerli FH, Opril S and Schork MA. 2006. Feasibility of treating prehypertension with an angiotensin-receptor blocker. N Engl J Med 354: 1685-1697. doi: 10.1056/NEJMoa060838.
• 4) Suzuki M, Hozumi N, Waki H, Kimura M, Seino T, Onuma N and Shindo D. 2019. Effects of combined therapy of ACE inhibitor and exercise on cardiovascular functions and morphology of the heart and kidneys in SHR. J Phys Fitness Sports Med 8: 229-240. doi: 10.7600/jpfsm.8.229.
• 5) Suzuki M, Hodumi N, Kimura M, Nakaya M, Shimizu T, Takao T, Magara T, Mori Y and Machida K. 2000. Effects of exercise and dietary therapies on renal function and morphological findings in the kidney and glucose-fatty metabolism in OLETF rats - use of OLETF rats as a model of type 2 diabetes mellitus. Tairyoku Kagaku (Jpn J Phys Fitness Sports Med) 49: 403-418 (in Japanese). doi: 10.7600/jspfsm1949.49.403.

Terms in the title (6)： ラット ,  糖尿病性腎症 ,  発症 ,  ACE阻害薬 ,  運動 ,  併用療法