Art

J-GLOBAL ID：202002244833629728   Reference number：20A0116877

Loss of Mitochondrial DNA by Gemcitabine Triggers Mitophagy and Cell Death

ゲムシタビンによるミトコンドリアDNAの消失はマイトファジーと細胞死を引き起こす

Author (3)： Inamura Akihiro (Division of Life Science, Department of Pharmacy, Hokkaido University of Science) ,  Muraoka-Hirayama Sanae (Division of Life Science, Department of Pharmacy, Hokkaido University of Science) ,  Sakurai Koichi (Division of Life Science, Department of Pharmacy, Hokkaido University of Science)
Material： Biological and Pharmaceutical Bulletin (Web)
Volume： 42  Issue： 12  Page： 1977-1987(J-STAGE)  Publication year： 2019 
JST Material Number： U1402A  ISSN： 1347-5215  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *antineoplastic antimetabolite ,...
Semi thesaurus term： Akt ,...

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Author keywords (10)： gemcitabine ,  mitochondrial DNA ,  mitophagy ,  cell death ,  mitochondrial membrane potential ,  gemcitabine ,  mitochondrial DNA ,  mitophagy ,  cell death ,  mitochondrial membrane potential

JST classification (2)： Basic research of antitumor(=antineoplastic)drugs  (GW16010A) ,  Basic oncology in general  (GE02010R)

Substance index (1)： Gemcitabine

Reference (64)：

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• 3) Paproski RJ, Young JD, Cass CE. Predicting gemcitabine transport and toxicity in human pancreatic cancer cell lines with the positron emission tomography tracer 3′-deoxy-3′-fluorothymidine. Biochem. Pharmacol., 79, 587-595 (2010).
• 4) Engelke CG, Parsels LA, Qian Y, Zhang Q, Karnak D, Robertson JR, Tanska DM, Wei D, Davis MA, Parsels JD, Zhao L, Greenson JK, Lawrence TS, Maybaum J, Morgan MA. Sensitization of pancreatic cancer to chemoradiation by the Chk1 inhibitor MK8776. Clin. Cancer Res., 19, 4412-4421 (2013).
• 5) Ikura T, Ogryzko VV, Grigoriev M, Groisman R, Wang J, Horikoshi M, Scully R, Qin J, Nakatani Y. Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis. Cell, 102, 463-473 (2000).

Terms in the title (4)： ゲムシタビン ,  ミトコンドリアDNA ,  マイトファジー ,  細胞死