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J-GLOBAL ID：202002247600586677   Reference number：20A1259067

Oct motif variants in Beckwith-Wiedemann syndrome patients disrupt maintenance of the hypomethylated state of the H19/IGF2 imprinting control region

beckwith-Wiedemann症候群患者におけるOCTモチーフ変異体はH19/IGF2インプリンティング制御領域の低メチル化状態の維持を破壊する【JST・京大機械翻訳】

Author (7)： Kubo Shuichi (Division of Molecular Biology, Faculty of Medicine, School of Life Sciences, Tottori University, Yonago, Japan) ,  Murata Chihiro (Division of Molecular Biology, Faculty of Medicine, School of Life Sciences, Tottori University, Yonago, Japan) ,  Okamura Hanayo (Division of Molecular Biology, Faculty of Medicine, School of Life Sciences, Tottori University, Yonago, Japan) ,  Sakasegawa Taku (Division of Molecular Biology, Faculty of Medicine, School of Life Sciences, Tottori University, Yonago, Japan) ,  Sakurai Chiye (Division of Molecular Biology, Faculty of Medicine, School of Life Sciences, Tottori University, Yonago, Japan) ,  Hatsuzawa Kiyotaka (Division of Molecular Biology, Faculty of Medicine, School of Life Sciences, Tottori University, Yonago, Japan) ,  Hori Naohiro (Division of Molecular Biology, Faculty of Medicine, School of Life Sciences, Tottori University, Yonago, Japan)
Material： FEBS Letters  (for the Rapid Publication of Short Reports in Biochemistry, Biophysics)
Volume： 594  Issue： 10  Page： 1517-1531  Publication year： 2020 
JST Material Number： D0575A  ISSN： 0014-5793  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： The methylation status of impr...

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Thesaurus term： *Methylation ,  *regulatory gene ,  demethylation ,  binding site ,  *imprinting ,  IGF2 ,  DNA Methylation ,  Transgenes ,  *H19 ,  DNA demethylation ,  factor ,  bioactive factor ,  growth factor ,  cytokine

Author keywords (6)： Beckwith-Wiedemann syndrome ,  CTCF-binding site ,  DNA demethylation ,  imprinting control center 1 ,  Oct motif-dependent regulation ,  P19 cell

JST classification (1)： Gene expression  (EC02040Q)

Terms in the title (11)： Beckwith-Wiedemann症候群 ,  患者 ,  OCT ,  モチーフ ,  変異体 ,  H19 ,  IGF2 ,  インプリンティング ,  制御領域 ,  低メチル化 ,  破壊