Art

J-GLOBAL ID：202002248406518018   Reference number：20A1825836

Discovery of a Potent Anticancer Agent PVHD303 with in Vivo Activity

in vivo活性を有する強力な抗癌剤PVHD303の発見【JST・京大機械翻訳】

Author (13)： Suzuki Yumiko (Department of Materials and Life Sciences, Faculty of Science and Technology, Sophia University, Japan) ,  Otake Ayana (School of Pharmaceutical Sciences, University of Shizuoka, Japan) ,  Ueno Satoshi (Pharmaceutical Research Department, Yakult Central Institute, Japan) ,  Hayashi Kensuke (Department of Materials and Life Sciences, Faculty of Science and Technology, Sophia University, Japan) ,  Ishii Hirosuke (Graduate School of Pharmaceutical Sciences, University of Shizuoka, Japan) ,  Miyoshi Nao (Graduate School of Pharmaceutical Sciences, University of Shizuoka, Japan) ,  Kuroiwa Kenta (Department of Materials and Life Sciences, Faculty of Science and Technology, Sophia University, Japan) ,  Tachikawa Masashi (Department of Materials and Life Sciences, Faculty of Science and Technology, Sophia University, Japan) ,  Fujimaki Yuki (Department of Materials and Life Sciences, Faculty of Science and Technology, Sophia University, Japan) ,  Nishiyama Kotaro (Department of Materials and Life Sciences, Faculty of Science and Technology, Sophia University, Japan) ,  Manabe Kei (School of Pharmaceutical Sciences, University of Shizuoka, Japan) ,  Yamazaki Ryuta (Pharmaceutical Research Department, Yakult Central Institute, Japan) ,  Asai Akira (Graduate School of Pharmaceutical Sciences, University of Shizuoka, Japan)
Material： ACS Medicinal Chemistry Letters
Volume： 11  Issue： 6  Page： 1287-1291  Publication year： 2020 
JST Material Number： W5043A  ISSN： 1948-5875  Document type： Article
Article type： 短報  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： As a part of our continuous st...

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Thesaurus term： *antitumor drug ,  structure-activity relationship ,  tumor ,  human(primates) ,  microtubule ,  heterotrans plantation ,  tubulin ,  cytotoxicity ,  centrosome ,  colonic neoplasm ,  A549 cell ,  nitrogen heterocyclic compound ,  polynuclear aromatic compound
Semi thesaurus term： 抗増殖活性 ,  肺癌細胞 ,  *in vivo活性 , 【Automatic Indexing@JST】

Author keywords (5)： Quinazoline ,  anticancer ,  tubulin inhibitors ,  structure-activity relationship ,  in vivo activity

JST classification (1)： Basic research of antitumor(=antineoplastic)drugs  (GW16010A)

Substance index (1)： Quinazoline

Terms in the title (3)： 活性 ,  抗癌剤 ,  発見