Art

J-GLOBAL ID：202002249133908836   Reference number：20A1172916

IMP dehydrogenase-2 drives aberrant nucleolar activity and promotes tumorigenesis in glioblastoma

IMPデヒドロゲナーゼ-2は膠芽腫において異常な核小体活性を駆動し,腫瘍形成を促進する【JST・京大機械翻訳】

Author (69)： Kofuji Satoshi (Division of Hematology and Oncology, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA) ,  Kofuji Satoshi (Graduate School of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan) ,  Hirayama Akiyoshi (Institute for Advanced Biosciences, Keio University, Tsuruoka, Japan) ,  Eberhardt Alexander Otto (Institute of Biochemistry and Biophysics, Center for Molecular Biomedicine, Friedrich Schiller University Jena, Jena, Germany) ,  Eberhardt Alexander Otto (Leibniz-Institute on Aging-Fritz Lipmann Institute, Jena, Germany) ,  Kawaguchi Risa (Division of Hematology and Oncology, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA) ,  Kawaguchi Risa (Artificial Intelligence Research Center, National Institute of Advanced Industrial Science and Technology, Tokyo, Japan) ,  Sugiura Yuki (Department of Biochemistry, Keio University School of Medicine, Tokyo, Japan) ,  Sampetrean Oltea (Division of Gene Regulation, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo, Japan) ,  Ikeda Yoshiki (Division of Hematology and Oncology, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA) ,  Warren Mikako (Division of Pathology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA) ,  Warren Mikako (Department of Pathology and Laboratory Medicine, Children’s Hospital Los Angeles and Keck School of Medicine, University of Southern California, Los Angeles, CA, USA) ,  Sakamoto Naoya (Graduate School of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan) ,  Kitahara Shuji (Department of Anatomy and Developmental Biology, Tokyo Women’s Medical University School of Medicine, Tokyo, Japan) ,  Yoshino Hirofumi (Division of Hematology and Oncology, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA) ,  Yamashita Daisuke (Department of Neurosurgery, University of Alabama at Birmingham, Birmingham, AL, USA) ,  Sumita Kazutaka (Division of Hematology and Oncology, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA) ,  Wolfe Kara (Division of Hematology and Oncology, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA) ,  Lange Lisa (Institute of Biochemistry and Biophysics, Center for Molecular Biomedicine, Friedrich Schiller University Jena, Jena, Germany) ,  Lange Lisa (Leibniz-Institute on Aging-Fritz Lipmann Institute, Jena, Germany) ,  Ikeda Satsuki (Institute for Advanced Biosciences, Keio University, Tsuruoka, Japan) ,  Shimada Hiroko (Division of Hematology and Oncology, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA) ,  Minami Noriaki (Division of Gene Regulation, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo, Japan) ,  Malhotra Akshiv (Division of Hematology and Oncology, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA) ,  Morioka Shin (Graduate School of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan) ,  Ban Yuki (Graduate School of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan) ,  Asano Maya (Graduate School of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan) ,  Flanary Victoria L. (Department of Neurosurgery, University of Alabama at Birmingham, Birmingham, AL, USA) ,  Ramkissoon Annmarie (Cancer and Blood Diseases Institute, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA) ,  Chow Lionel M. L. (Cancer and Blood Diseases Institute, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA) ,  Kiyokawa Juri (Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA) ,  Mashimo Tomoyuki (Department of Internal Medicine; Harold C. Simmons Comprehensive Cancer Center; Annette G. Strauss Center for Neuro-Oncology, University of Texas Southwestern Medical Center, Dallas, TX, USA) ,  Lucey Greg (Division of Neuropathology, Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA) ,  Mareninov Sergey (Division of Neuropathology, Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA) ,  Ozawa Tatsuya (Division of Human Biology, Solid Tumor and Translational Research, Fred Hutchinson Cancer Research Center, Seattle, WA, USA) ,  Onishi Nobuyuki (Division of Gene Regulation, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo, Japan) ,  Okumura Koichi (Division of Hematology and Oncology, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA) ,  Terakawa Jumpei (Division of Transgenic Animal Science, Advanced Science Research Center, Kanazawa University, Kanazawa, Japan) ,  Daikoku Takiko (Division of Transgenic Animal Science, Advanced Science Research Center, Kanazawa University, Kanazawa, Japan) ,  Wise-Draper Trisha (Division of Hematology and Oncology, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA) ,  Majd Nazanin (Department of Neurology, University of Cincinnati College of Medicine, Cincinnati, OH, USA) ,  Kofuji Kaori (Division of Hematology and Oncology, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA) ,  Sasaki Mika (Division of Hematology and Oncology, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA) ,  Mori Masaru (Institute for Advanced Biosciences, Keio University, Tsuruoka, Japan) ,  Kanemura Yonehiro (Department of Biomedical Research and Innovation, Institute for Clinical Research, National Hospital Organization Osaka National Hospital, Osaka, Japan) ,  Smith Eric P. (Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA) ,  Anastasiou Dimitrios (Cancer Metabolism Laboratory, The Francis Crick Institute, London, UK) ,  Wakimoto Hiroaki (Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA) ,  Holland Eric C. (Division of Human Biology, Solid Tumor and Translational Research, Fred Hutchinson Cancer Research Center, Seattle, WA, USA) ,  Yong William H. (Division of Neuropathology, Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA) ,  Horbinski Craig (Department of Pathology, University of Kentucky College of Medicine, Lexington, KY, USA) ,  Horbinski Craig (Departments of Pathology and Neurosurgery, Northwestern University, Chicago, IL, USA) ,  Nakano Ichiro (Department of Neurosurgery, University of Alabama at Birmingham, Birmingham, AL, USA) ,  DeBerardinis Ralph J. (Howard Hughes Medical Institute; Children’s Medical Center Research Institute; Department of Pediatrics and Eugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, TX, USA) ,  Bachoo Robert M. (Department of Internal Medicine; Harold C. Simmons Comprehensive Cancer Center; Annette G. Strauss Center for Neuro-Oncology, University of Texas Southwestern Medical Center, Dallas, TX, USA) ,  Bachoo Robert M. (Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, TX, USA) ,  Mischel Paul S. (Ludwig Institute for Cancer Research; Department of Pathology; Moores Cancer Center, University of California San Diego School of Medicine, La Jolla, CA, USA) ,  Yasui Wataru (Graduate School of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan) ,  Suematsu Makoto (Department of Biochemistry, Keio University School of Medicine, Tokyo, Japan) ,  Saya Hideyuki (Division of Gene Regulation, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo, Japan) ,  Soga Tomoyoshi (Institute for Advanced Biosciences, Keio University, Tsuruoka, Japan) ,  Soga Tomoyoshi (AMED-CREST, AMED, Tokyo, Japan) ,  Grummt Ingrid (Division of Molecular Biology of the Cell II, German Cancer Research Center, DKFZ-ZMBH Alliance, Heidelberg, Germany) ,  Bierhoff Holger (Institute of Biochemistry and Biophysics, Center for Molecular Biomedicine, Friedrich Schiller University Jena, Jena, Germany) ,  Bierhoff Holger (Leibniz-Institute on Aging-Fritz Lipmann Institute, Jena, Germany) ,  Sasaki Atsuo T. (Division of Hematology and Oncology, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA) ,  Sasaki Atsuo T. (Institute for Advanced Biosciences, Keio University, Tsuruoka, Japan) ,  Sasaki Atsuo T. (Department of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH, USA) ,  Sasaki Atsuo T. (Department of Neurosurgery, Brain Tumor Center at UC Gardner Neuroscience Institute, Cincinnati, OH, USA)
Material： Nature Cell Biology  (Nat Cell Biol)
Volume： 21  Issue： 8  Page： 1003-1014  Publication year： 2019 
JST Material Number： W1369A  ISSN： 1465-7392  Document type： Article
Article type： 原著論文  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Abstract/Point： Abstract: In many cancers, hig...

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Thesaurus term： enzyme ,  biosynthesis ,  rRNA ,  tRNA ,  heredity ,  cell proliferation ,  glia cell ,  glioma ,  pharmacology ,  perturbation ,  up-regulation ,  *tumorigenesis ,  p53 protein ,  *glioblastoma
Semi thesaurus term： 過剰発現 , 【Automatic Indexing@JST】

JST classification (2)： Chemistry,biochemistry and pathology of tumors(=neoplasms)  (GE02030N) ,  Biological function  (EB03040U)

Terms in the title (6)： IMPデヒドロゲナーゼ ,  膠芽腫 ,  核小体 ,  活性 ,  腫瘍形成 ,  促進