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J-GLOBAL ID：202002255587590135   Reference number：20A0886420

Alzheimer Aβ Assemblies Accumulate in Excitatory Neurons upon Proteasome Inhibition and Kill Nearby NAKα3 Neurons by Secretion

Alzheimer Aβ集合体は分泌によりプロテアソーム阻害において興奮性ニューロンに蓄積し,近傍Nakα3ニューロンを殺す【JST・京大機械翻訳】

Author (19)： Komura Hitomi (Department of Brain and Neurodegenerative Disease Research, Institute of Biomedical Research and Innovation, Foundation for Biomedical Research and Innovation at Kobe, Kobe 650-0047, Japan) ,  Komura Hitomi (TAO Health Life Pharma Co., Ltd., Med-Pharma Collaboration Bldg, Kyoto University, 46-29 Yoshida Shimoadachi-cho, Sakyo-ku, Kyoto 606-8501, Japan) ,  Kakio Shota (Department of Brain and Neurodegenerative Disease Research, Institute of Biomedical Research and Innovation, Foundation for Biomedical Research and Innovation at Kobe, Kobe 650-0047, Japan) ,  Kakio Shota (TAO Health Life Pharma Co., Ltd., Med-Pharma Collaboration Bldg, Kyoto University, 46-29 Yoshida Shimoadachi-cho, Sakyo-ku, Kyoto 606-8501, Japan) ,  Sasahara Tomoya (Department of Brain and Neurodegenerative Disease Research, Institute of Biomedical Research and Innovation, Foundation for Biomedical Research and Innovation at Kobe, Kobe 650-0047, Japan) ,  Sasahara Tomoya (TAO Health Life Pharma Co., Ltd., Med-Pharma Collaboration Bldg, Kyoto University, 46-29 Yoshida Shimoadachi-cho, Sakyo-ku, Kyoto 606-8501, Japan) ,  Arai Yoshie (Department of Brain and Neurodegenerative Disease Research, Institute of Biomedical Research and Innovation, Foundation for Biomedical Research and Innovation at Kobe, Kobe 650-0047, Japan) ,  Arai Yoshie (TAO Health Life Pharma Co., Ltd., Med-Pharma Collaboration Bldg, Kyoto University, 46-29 Yoshida Shimoadachi-cho, Sakyo-ku, Kyoto 606-8501, Japan) ,  Takino Naomi (Division of Neurology, Jichi Medical University, Shimotsuke 329-0498, Japan) ,  Sato Michio (Meiji University, Graduate School of Agriculture, Meiji University, Kawasaki 214-8571, Japan) ,  Satomura Kaori (Department of Brain and Neurodegenerative Disease Research, Institute of Biomedical Research and Innovation, Foundation for Biomedical Research and Innovation at Kobe, Kobe 650-0047, Japan) ,  Satomura Kaori (TAO Health Life Pharma Co., Ltd., Med-Pharma Collaboration Bldg, Kyoto University, 46-29 Yoshida Shimoadachi-cho, Sakyo-ku, Kyoto 606-8501, Japan) ,  Ohnishi Takayuki (Department of Brain and Neurodegenerative Disease Research, Institute of Biomedical Research and Innovation, Foundation for Biomedical Research and Innovation at Kobe, Kobe 650-0047, Japan) ,  Ohnishi Takayuki (TAO Health Life Pharma Co., Ltd., Med-Pharma Collaboration Bldg, Kyoto University, 46-29 Yoshida Shimoadachi-cho, Sakyo-ku, Kyoto 606-8501, Japan) ,  Nabeshima Yo-ichi (Department of Gerontology, Institute of Biomedical Research and Innovation, Foundation for Biomedical Research and Innovation at Kobe, Kobe 650-0047, Japan) ,  Muramatsu Shin-ichi (Division of Neurology, Jichi Medical University, Shimotsuke 329-0498, Japan) ,  Muramatsu Shin-ichi (Center for Gene & Cell Therapy, The Institute of Medical Science, University of Tokyo, Tokyo 108-0071, Japan) ,  Kii Isao (RIKEN Center for Life Science Technologies, Division of Bio-Function Dynamics Imaging, Kobe 650-0047, Japan) ,  Hoshi Minako (Department of Anatomy and Developmental Biology, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan)
Material： iScience
Volume： 13  Page： 452-477  Publication year： 2019 
JST Material Number： W5512A  ISSN： 2589-0042  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： We identified ~30-mer amyloid-...

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Thesaurus term： *neuron ,  in vitro experiment ,  *proteasome ,  *aggregate ,  network ,  amyloid ,  apoptosis ,  amyloid beta-protein ,  neuroscience ,  *Alzheimer disease ,  dendrite(neuron) ,  axon
Semi thesaurus term： スフェロイド ,  神経変性 ,  興奮性ニューロン , 【Automatic Indexing@JST】

Author keywords (3)： Pathophysiology ,  Neuroscience ,  Cellular Neuroscience

JST classification (2)： Basic neurology  (GN01020W) ,  Nervous system diseases  (GN03000O)

Terms in the title (8)： Alzheimer ,  集合体 ,  分泌 ,  プロテアソーム阻害 ,  興奮性ニューロン ,  蓄積 ,  近傍 ,  ニューロン