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J-GLOBAL ID：202002259242258401   Reference number：20A2096103

Low Levels of Brain-Derived Neurotrophic Factor Trigger Self-aggregated Amyloid β-Induced Neuronal Cell Death in an Alzheimer’s Cell Model

低レベル脳由来神経栄養因子はAlzheimer細胞モデルにおける自己凝集アミロイドβ誘導神経細胞死を誘発する

Author (7)： Tagai Nozomi (Department of Biochemistry, Faculty of Pharmaceutical Sciences, Tokyo University of Science) ,  Tagai Nozomi (Department of Gene Regulation, Faculty of Pharmaceutical Sciences, Tokyo University of Science) ,  Tanaka Ayako (Department of Biochemistry, Faculty of Pharmaceutical Sciences, Tokyo University of Science) ,  Tanaka Ayako (Department of Gene Regulation, Faculty of Pharmaceutical Sciences, Tokyo University of Science) ,  Sato Akira (Department of Biochemistry, Faculty of Pharmaceutical Sciences, Tokyo University of Science) ,  Uchiumi Fumiaki (Department of Gene Regulation, Faculty of Pharmaceutical Sciences, Tokyo University of Science) ,  Tanuma Sei-ichi (Department of Genomic Medicinal Science, Research Institute for Science and Technology, Organization for Research Advancement, Tokyo University of Science)
Material： Biological and Pharmaceutical Bulletin (Web)
Volume： 43  Issue： 7  Page： 1073-1080(J-STAGE)  Publication year： 2020 
JST Material Number： U1402A  ISSN： 1347-5215  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： Alzheimer Disease ,...
Semi thesaurus term： *BDNF ,...

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Author keywords (12)： amyloid β ,  brain derived neurotrophic factor ,  neurite fragmentation ,  neuronal cell death ,  SH-SY5Y cell ,  Alzheimer’s cell model ,  amyloid β ,  brain derived neurotrophic factor ,  neurite fragmentation ,  neuronal cell death ,  SH-SY5Y cell ,  Alzheimer’s cell model

JST classification (2)： Basic neurology  (GN01020W) ,  Cell physiology in general  (EF02010S)

Reference (37)：

• 1) Scheff SW, Price DA, Schmitt FA, Mufson EJ. Hippocampal synaptic loss in early Alzheimer’s disease and mild cognitive impairment. Neurobiol. Aging, 27, 1372-1384 (2006).
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• 3) Duyckaerts C, Delatour B, Potier MC. Classification and basic pathology of Alzheimer disease. Acta Neuropathol., 118, 5-36 (2009).
• 4) Fricker M, Tolkovsky AM, Borutaite V, Coleman M, Brown GC. Neuronal cell death. Physiol. Rev., 98, 813-880 (2018).
• 5) Scheltens P, Blennow K, Breteler MM, de Strooper B, Frisoni GB, Salloway S, Van der Flier WM. Alzheimer’s disease. Lancet, 388, 505-517 (2016).

Terms in the title (8)： 脳由来神経栄養因子 ,  Alzheimer ,  細胞モデル ,  自己凝集 ,  アミロイドβ ,  誘導 ,  神経細胞死 ,  誘発