Art

J-GLOBAL ID：202002259549110462   Reference number：20A2229587

Impaired actin filaments decrease cisplatin sensitivity via dysfunction of volume-sensitive Cl^- channels in human epidermoid carcinoma cells

アクチン線維損傷はヒト類表皮癌細胞における容積感受性Cl-チャンネルの機能不全を介してシスプラチン感受性を低下させる【JST・京大機械翻訳】

Author (7)： Shimizu Takahiro (Department of Pharmaceutical Physiology, Faculty of Pharmaceutical Sciences, University of Toyama, Toyama, Japan) ,  Fujii Takuto (Department of Pharmaceutical Physiology, Faculty of Pharmaceutical Sciences, University of Toyama, Toyama, Japan) ,  Ohtake Hironao (Department of Pharmaceutical Physiology, Faculty of Pharmaceutical Sciences, University of Toyama, Toyama, Japan) ,  Tomii Toshie (Department of Pharmaceutical Physiology, Faculty of Pharmaceutical Sciences, University of Toyama, Toyama, Japan) ,  Takahashi Ryuta (Department of Pharmaceutical Physiology, Faculty of Pharmaceutical Sciences, University of Toyama, Toyama, Japan) ,  Kawashima Kentaro (Department of Pharmaceutical Physiology, Faculty of Pharmaceutical Sciences, University of Toyama, Toyama, Japan) ,  Sakai Hideki (Department of Pharmaceutical Physiology, Faculty of Pharmaceutical Sciences, University of Toyama, Toyama, Japan)
Material： Journal of Cellular Physiology  (J Cell Physiol)
Volume： 235  Issue： 12  Page： 9589-9600  Publication year： 2020 
JST Material Number： E0042B  ISSN： 0021-9541  CODEN： JCLLA  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： Cisplatin is a widely used pla...

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Thesaurus term： electric current ,  swelling ,  depolymerization ,  *actin ,  *tumor cell ,  human(primates) ,  drug therapy ,  *cisplatin ,  *actin filament ,  *squamous cell carcinoma ,  apoptosis ,  macrocyclic compound ,  aromatic compound ,  lactam ,  diene ,  aliphatic carboxylic acid ,  olefin compound ,  carboxylate(ester) ,  hydroxy ketone ,  polyol
Semi thesaurus term： KB細胞 ,  蛋白質発現 ,  シスプラチン耐性 , 【Automatic Indexing@JST】

Author keywords (5)： actin filaments ,  apoptosis ,  cell volume ,  chloride channels ,  cisplatin

JST classification (2)： Basic research of antitumor(=antineoplastic)drugs  (GW16010A) ,  Cell physiology in general  (EF02010S)

Substance index (1)： Cytochalasin D

Terms in the title (10)： アクチン線維 ,  損傷 ,  ヒト ,  類表皮癌 ,  細胞 ,  容積 ,  感受性 ,  チャンネル ,  機能不全 ,  シスプラチン