Art

J-GLOBAL ID：202002261824930293   Reference number：20A0600457

PCDH17 functions as a common tumor suppressor gene in acute leukemia and its transcriptional downregulation is mediated primarily by aberrant histone acetylation, not DNA methylation

PCDH17は急性白血病における一般的な腫瘍抑制遺伝子として機能し,その転写のダウンレギュレーションは主にDNAメチル化ではなく異常なヒストンアセチル化によって媒介される

Author (11)： Thanh Nha Uyen Le (Department of Medical Genetics, Hue University of Medicine and Pharmacy, Hue, Vietnam) ,  Thanh Nha Uyen Le (Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Nagano, Japan) ,  Amano Yuji (Department of Microbiology and Immunology, Shinshu University School of Medicine, Matsumoto, Nagano, Japan) ,  Al-Kzayer Lika'a Fasih Y. (Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Nagano, Japan) ,  Kubota Noriko (Department of Laboratory Medicine, Nagano Children’s Hospital, Azumino, Japan) ,  Kobayashi Jun (Department of Laboratory Medicine, Nagano Children’s Hospital, Azumino, Japan) ,  Nakazawa Yozo (Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Nagano, Japan) ,  Koike Kenichi (Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Nagano, Japan) ,  Koike Kenichi (Shinonoi General Hospital, Minami Nagano Center, Nagano, Japan) ,  Sakashita Kazuo (Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Nagano, Japan) ,  Sakashita Kazuo (Department of Hematology and Oncology, Nagano Children’s Hospital, Azumino, Nagano, Japan)
Material： International Journal of Hematology  (Int J Hematol)
Volume： 111  Issue： 3  Page： 451-462  Publication year： Mar. 2020 
JST Material Number： F0888A  ISSN： 0925-5710  CODEN： IJHEEY  Document type： Article
Article type： 原著論文  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Thesaurus term： acute myeloid leukemia ,...
Semi thesaurus term： infantile disease ,...

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Author keywords (5)： PCDH17 gene ,  Protocadherin ,  Leukemia ,  Histone acetylation ,  DNA methylation

JST classification (3)： Basic hematology  (GK01020N) ,  Chemistry,biochemistry and pathology of tumors(=neoplasms)  (GE02030N) ,  Basic research of antitumor(=antineoplastic)drugs  (GW16010A)

Substance index (2)： Trichostatin A ,  Azacitidine

Terms in the title (6)： 急性白血病 ,  腫瘍抑制遺伝子 ,  転写 ,  ダウンレギュレーション ,  DNAメチル化 ,  ヒストンアセチル化