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J-GLOBAL ID：202002261966461951   Reference number：20A0247629

Magnolol protects PC12 cells from hydrogen peroxide or 6-hydroxydopamine induced cytotoxicity

マグノロールは過酸化水素または6-ヒドロキシドーパミン誘発細胞毒性からPC12細胞を保護する

Author (6)： Nishiyama Takahito (Department of Drug Metabolism and Molecular Toxicology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences) ,  Masuda Yasuhiro (Department of Drug Metabolism and Molecular Toxicology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences) ,  Izawa Tadashi (Department of Drug Metabolism and Molecular Toxicology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences) ,  Ohnuma Tomokazu (Department of Drug Metabolism and Molecular Toxicology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences) ,  Ogura Kenichiro (Department of Drug Metabolism and Molecular Toxicology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences) ,  Hiratsuka Akira (Department of Drug Metabolism and Molecular Toxicology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences)
Material： Journal of Toxicological Sciences  (日本毒性学会学術年会プログラム・要旨集)
Volume： 44  Issue： 11  Page： 753-758(J-STAGE)  Publication year： 2019 
JST Material Number： Z0265B  ISSN： 0388-1350  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： Magnolia ,...
Semi thesaurus term： plant extract

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Author keywords (6)： Catalase ,  Honokiol ,  Magnolol ,  NAD(P)H:Quinone oxidoreductase 1 ,  Oxidative stress ,  PC12 cells

JST classification (2)： Basic research of pharmacology of crude drugs  (GX06020J) ,  Cell physiology in general  (EF02010S)

Substance index (3)： 6-Hydroxydopamine ,  Honokiol ,  Magnolol

Reference (16)：

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• Kuribara, H., Stavinoha, W.B. and Maruyama, Y. (1998): Havioural pharmacological characteristics of honokiol, an anxiolytic agent present in extracts of Magnolia bark, evaluated by an elevated plus-maze test in mice. J. Pharm. Pharmacol., 50, 819-826.
• Li, Y., Xu, C., Zhang, Q., Liu, J.Y. and Tan, R.X. (2005): In vitro anti-Helicobacter pylori action of 30 Chinese herbal medicines used to treat ulcer diseases. J. Ethnopharmacol., 98, 329-333.
• Nishiyama, T., Ohnuma, T., Inoue, Y., Kishi, T., Ogura, K. and Hiratsuka, A. (2008): UDP-glucuronosyltransferases 1A6 and 1A10 catalyze reduced menadione glucuronidation. Biochem. Biophys. Res. Commun., 371, 247-250.

Terms in the title (6)： マグノロール ,  過酸化水素 ,  6-ヒドロキシドーパミン ,  誘発 ,  細胞毒性 ,  PC12細胞