Art

J-GLOBAL ID：202002263621869742   Reference number：20A2512747

Peroxisome Deficiency Impairs BDNF Signaling and Memory

ペルオキシソーム欠損はBDNFシグナル伝達と記憶を損なう【JST・京大機械翻訳】

Author (11)： Abe Yuichi (Division of Organelle Homeostasis, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan) ,  Abe Yuichi (Faculty of Arts and Science, Kyushu University, Fukuoka, Japan) ,  Nishimura Yoshiki (Graduate School of Systems Life Sciences, Kyushu University, Fukuoka, Japan) ,  Nakamura Kaori (Graduate School of Systems Life Sciences, Kyushu University, Fukuoka, Japan) ,  Tamura Shigehiko (Faculty of Arts and Science, Kyushu University, Fukuoka, Japan) ,  Tamura Shigehiko (Graduate School of Systems Life Sciences, Kyushu University, Fukuoka, Japan) ,  Honsho Masanori (Institute of Rheological Functions of Food, Fukuoka, Japan) ,  Udo Hiroshi (Graduate School of Systems Life Sciences, Kyushu University, Fukuoka, Japan) ,  Yamashita Toshihide (Department of Molecular Neuroscience, Graduate School of Medicine, Osaka University, Suita, Japan) ,  Fujiki Yukio (Division of Organelle Homeostasis, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan) ,  Fujiki Yukio (Institute of Rheological Functions of Food, Fukuoka, Japan)
Material： Frontiers in Cell and Developmental Biology (Web)
Volume： 8  Page： 567017  Publication year： 2020 
JST Material Number： U7062A  ISSN： 2296-634X  Document type： Article
Article type： 原著論文  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： Peroxisome is an intracellular...

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Thesaurus term： oxidation ,  neuron ,  plasma(blood) ,  biosynthesis ,  receptor ,  hippocampus ,  metabolic pathway ,  *peroxisome ,  adult(development) ,  cell organelle ,  *cellular signal transduction ,  up-regulation ,  *BDNF ,  knockout mouse
Semi thesaurus term： trkB受容体 , 【Automatic Indexing@JST】

Author keywords (7)： peroxisome ,  Pex2 ,  conditional knockout ,  memory disturbance ,  neural stem cell ,  BDNF ,  TrkB

JST classification (1)： Congenital diseases,deformities in general.  (GD03010V)

Reference (48)：

• AbeY.HonshoM.ItohR.KawaguchiR.FujitaniM.FujiwaraK. (2018). Peroxisome biogenesis deficiency attenuates the BDNF-TrkB pathway-mediated development of the cerebellum. Life Sci. Alliance 1:e201800062. doi: 10.26508/lsa.201800062 30519675
• AbeY.HonshoM.KawaguchiR.MatsuzakiT.IchikiY.FujitaniM. (2020). A peroxisome deficiency-induced reductive cytosol state up-regulates the brain-derived neurotrophic factor pathway. J. Biol. Chem. 295 5321-5334. doi: 10.1074/jbc.ra119.011989 32165495
• AbeY.HonshoM.NakanishiH.TaguchiR.FujikiY. (2014). Very-long-chain polyunsaturated fatty acids accumulate in phosphatidylcholine of fibroblasts from patients with Zellweger syndrome and acyl-CoA oxidase1 deficiency. Biochim. Biophys. Acta Mol. Cell Biol. Lipids 1841 610-619. doi: 10.1016/j.bbalip.2014.01.001 24418004
• BaesM.GressensP.BaumgartE.CarmelietP.CasteelsM.FransenM. (1997). A mouse model for Zellweger syndrome. Nat. Genet. 17 49-57. doi: 10.1038/ng0997-49 9288097
• BlighE. G.DyerW. J. (1959). A rapid method of total lipid extraction and purification. Can. J. Biochem. Physiol. 37 911-917. doi: 10.1139/o59-099 13671378

Terms in the title (4)： ペルオキシソーム ,  欠損 ,  BDNF ,  シグナル伝達