Art

J-GLOBAL ID：202002265377739871   Reference number：20A0896882

Trans-biobank analysis with 676,000 individuals elucidates the association of polygenic risk scores of complex traits with human lifespan

リスク予測:67万6000人に対するバイオバンク横断解析で明らかになった,複雑形質の多遺伝子性リスクスコアとヒト寿命との関連

Author (36)： SAKAUE Saori (Lab. for Statistical Analysis, RIKEN Center for Integrative Medical Sci., Yokohama, JPN) ,  KANAI Masahiro (Lab. for Statistical Analysis, RIKEN Center for Integrative Medical Sci., Yokohama, JPN) ,  AKIYAMA Masato (Lab. for Statistical Analysis, RIKEN Center for Integrative Medical Sci., Yokohama, JPN) ,  MATOBA Nana (Lab. for Statistical Analysis, RIKEN Center for Integrative Medical Sci., Yokohama, JPN) ,  TAKAHASHI Atsushi (Lab. for Statistical Analysis, RIKEN Center for Integrative Medical Sci., Yokohama, JPN) ,  KAMATANI Yoichiro (Lab. for Statistical Analysis, RIKEN Center for Integrative Medical Sci., Yokohama, JPN) ,  SAKAUE Saori (Dep. of Statistical Genetics, Osaka Univ. Graduate School of Medicine, Suita, JPN) ,  KANAI Masahiro (Dep. of Statistical Genetics, Osaka Univ. Graduate School of Medicine, Suita, JPN) ,  OKADA Yukinori (Dep. of Statistical Genetics, Osaka Univ. Graduate School of Medicine, Suita, JPN) ,  SAKAUE Saori (Dep. of Allergy and Rheumatology, Graduate School of Medicine, Univ. Tokyo, Tokyo, JPN) ,  KANAI Masahiro (Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA) ,  KARJALAINEN Juha (Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA) ,  KURKI Mitja (Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA) ,  DALY Mark J. (Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA) ,  KANAI Masahiro (Program in Medical and Population Genetics, Broad Inst. of Harvard and MIT, Cambridge, MA, USA) ,  KARJALAINEN Juha (Program in Medical and Population Genetics, Broad Inst. of Harvard and MIT, Cambridge, MA, USA) ,  KURKI Mitja (Program in Medical and Population Genetics, Broad Inst. of Harvard and MIT, Cambridge, MA, USA) ,  DALY Mark J. (Program in Medical and Population Genetics, Broad Inst. of Harvard and MIT, Cambridge, MA, USA) ,  KANAI Masahiro (Stanley Center for Psychiatric Res., Broad Inst. of Harvard and MIT, Cambridge, MA, USA) ,  KARJALAINEN Juha (Stanley Center for Psychiatric Res., Broad Inst. of Harvard and MIT, Cambridge, MA, USA) ,  KURKI Mitja (Stanley Center for Psychiatric Res., Broad Inst. of Harvard and MIT, Cambridge, MA, USA) ,  DALY Mark J. (Stanley Center for Psychiatric Res., Broad Inst. of Harvard and MIT, Cambridge, MA, USA) ,  KANAI Masahiro (Dep. of Biomedical Informatics, Harvard Medical School, Boston, MA, USA) ,  KANAI Masahiro (Inst. for Molecular Medicine Finland (FIMM), Univ. Helsinki, Helsinki, FIN) ,  KARJALAINEN Juha (Inst. for Molecular Medicine Finland (FIMM), Univ. Helsinki, Helsinki, FIN) ,  KURKI Mitja (Inst. for Molecular Medicine Finland (FIMM), Univ. Helsinki, Helsinki, FIN) ,  DALY Mark J. (Inst. for Molecular Medicine Finland (FIMM), Univ. Helsinki, Helsinki, FIN) ,  AKIYAMA Masato (Dep. of Ophthalmology, Graduate School of Medical Sci., Kyushu Univ., Fukuoka, Fukuoka, JPN) ,  TAKAHASHI Atsushi (Dep. of Genomic Medicine, Res. Inst., National Cerebral and Cardiovascular Center, Suita, JPN) ,  HIRATA Makoto (Lab. of Genome Technol., Inst. of Medical Sci., Univ. Tokyo, Tokyo, JPN) ,  KUBO Michiaki (RIKEN Center for Integrative Medical Sci., Yokohama, JPN) ,  MATSUDA Koichi (Dep. of Computational Biology and Medical Sci., Graduate School of Frontier Sci., Univ. Tokyo, Tokyo, JPN) ,  MURAKAMI Yoshinori (Div. of Molecular Pathology, Inst. of Medical Sci., Univ. Tokyo, Tokyo, JPN) ,  KAMATANI Yoichiro (Lab. of Complex Trait Genomics, Dep. of Computational Biology and Medical Sci., Graduate School of Frontier Sci., Univ. Tokyo, Tokyo, JPN) ,  OKADA Yukinori (Lab. of Statistical Immunology, Immunology Frontier Res. Center (WPI-IFReC), Osaka Univ., Suita, JPN) ,  OKADA Yukinori (Integrated Frontier Res. for Medical Sci. Div., Inst. for Open and Transdisciplinary Res. Initiatives, Osaka Univ., Suita, JPN)
Material： Nature Medicine  (Nat Med)
Volume： 26  Issue： 4  Page： 542-548  Publication year： Apr. 2020 
JST Material Number： W0636A  ISSN： 1078-8956  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： genotype ,  risk factor ,  United Kingdom ,  systolic blood pressure ,  blood pressure ,  *human(primates) ,  biomarker ,  *gene ,  obesity ,  sensitivity ,  phenotype
Semi thesaurus term： ハザード比 ,  健康リスク ,  *リスクスコア ,  *バイオバンク , 【Automatic Indexing@JST】

JST classification (5)： Molecular genetics in general  (EC02010J) ,  Basic neurology  (GN01020W) ,  Basic medicine on urogenital system  (GM01020T) ,  Metabolic diseases,nutritional diseases in general.  (GD05010J) ,  Research methods in genetics  (EC01020N)

Terms in the title (8)： リスク予測 ,  バイオバンク ,  解析 ,  形質 ,  遺伝子 ,  リスクスコア ,  ヒト ,  寿命