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J-GLOBAL ID：202002269479299936   Reference number：20A2757245

Association of CYP2A6 gene deletion with cancers in Japanese elderly: an autopsy study

日本人高齢者におけるCYP2A6遺伝子欠失と癌との関連:剖検研究【JST・京大機械翻訳】

Author (6)： Abudushataer Maidina (Department of Molecular Epidemiology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan) ,  Sato Noriko (Department of Molecular Epidemiology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan) ,  Mieno Makiko (Center for Information, Jichi Medical University, Tochigi, Japan) ,  Sawabe Motoji (Department of Molecular Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan) ,  Muramatsu Masaaki (Department of Molecular Epidemiology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan) ,  Arai Tomio (Department of Pathology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan)
Material： BMC Cancer (Web)
Volume： 20  Issue： 1  Page： 1-8  Publication year： 2020 
JST Material Number： U7305A  ISSN： 1471-2407  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Abstract/Point： CYP2A6 is an enzyme involved i...

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Thesaurus term： database ,  enzyme ,  Genotype ,  smoking (tobacco) ,  carcinogenicity ,  allele ,  *Autopsy ,  wild type ,  stomach tumor ,  RT-PCR ,  *gene deficiency ,  single nucleotide polymorphism ,  gene typing ,  nitrogen heterocyclic compound ,  drug ,  tobacco alkaloid
Semi thesaurus term： 喫煙者 , 【Automatic Indexing@JST】

Author keywords (5)： CYP2A6*1 ,  CYP2A6*4 ,  Pathology ,  Cancer ,  Smoking

JST classification (2)： Tumors(=neoplasms)of respiratory system  (GI04000G) ,  Clinical oncology in general  (GE03010Y)

Substance index (1)： Nicotine

Reference (27)：

• Pharmacogenet Genomics; PharmGKB summary - very important Pharmacogene information for cytochrome P-450, family 2, subfamily a, polypeptide 6; EM McDonagh, C Wassenaar, SP David, RF Tyndale, RB Altman, M Whirl-Carrillo, TE Klein; 22; 9; 2012; 695-708; 10.1097/FPC.0b013e3283540217; citation_id=CR1
• J Pers Med; Variation in CYP2A6 activity and personalized medicine; JA Tanner, RF Tyndale; 7; 4; 2017; pii: E18; 10.3390/jpm7040018; citation_id=CR2
• Chem Res Toxicol; Nicotine metabolism and smoking: ethnic differences in the role of P450 2A6; SE Murphy; 30; 1; 2017; 410-419; 10.1021/acs.chemrestox.6b00387; citation_id=CR3
• Carcinogenesis; Alaska native smokers and smokeless tobacco users with slower CYP2A6 activity have lower tobacco consumption, lower tobacco-specific nitrosamine exposure and lower tobacco-specific nitrosamine bioactivation; AZ Zhu, MJ Binnington, CC Renner, AP Lanier, DK Hatsukami, I Stepanov, CH Watson, CS Sosnoff, NL Benowitz, RF Tyndale; 34; 1; 2013; 93-101; 10.1093/carcin/bgs306; citation_id=CR4
• Carcinogenesis; CYP2A6 genetic polymorphisms and biomarkers of tobacco smoke constituents in relation to risk of lung cancer in the Singapore Chinese health study; JM Yuan, HH Nelson, SG Carmella, R Wang, J Kuriger-Laber, A Jin, J Adams-Haduch, SS Hecht, WP Koh, SE Murphy; 38; 2017; 411-418; 10.1093/carcin/bgx012; citation_id=CR5

Terms in the title (7)： 日本人 ,  高齢者 ,  CYP2A6遺伝子 ,  欠失 ,  癌 ,  剖検 ,  研究