Art

J-GLOBAL ID：202002272047220475   Reference number：20A0116885

A Genome-Wide Association Study Identifies Five Novel Genetic Markers for Trastuzumab-Induced Cardiotoxicity in Japanese Population

ゲノムワイド関連研究は日本人集団におけるトラスツズマブ誘導心毒性に対する5つの新規遺伝マーカーを同定する

Author (21)： Nakano Mari Hara (Project for Development of Liquid Biopsy Diagnosis, Japanese Foundation for Cancer Research, Research Institute) ,  Nakano Mari Hara (Division of Breast and Endocrine Surgery, Department of Surgery, St.Marianna University School of Medicine) ,  Udagawa Chihiro (Project for Development of Liquid Biopsy Diagnosis, Japanese Foundation for Cancer Research, Research Institute) ,  Udagawa Chihiro (New Business Development Life Science Group, Toyo Kohan Co., Ltd.) ,  Shimo Arata (Division of Breast and Endocrine Surgery, Department of Surgery, St.Marianna University School of Medicine) ,  Kojima Yasuyuki (Division of Breast and Endocrine Surgery, Department of Surgery, St.Marianna University School of Medicine) ,  Yoshie Reiko (Division of Breast and Endocrine Surgery, Department of Surgery, St.Marianna University School of Medicine) ,  Zaha Hisamitsu (Department of Breast Surgery, Nakagami Hospital) ,  Abe Norie (Department of Breast Surgery, Nakagami Hospital) ,  Motonari Tokiwa (Department of Breast Surgery, Nakagami Hospital) ,  Unesoko Mikiko (Department of Breast Surgery, Nakagami Hospital) ,  Tamura Kenji (Department of Breast and Medical Oncology, National Cancer Center Hospital) ,  Shimoi Tatsunori (Department of Breast and Medical Oncology, National Cancer Center Hospital) ,  Yoshida Masayuki (Department of Pathology and Clinical Laboratories, National Cancer Center Hospital) ,  Yoshida Teruhiko (Fundamental Innovative Oncology Core, National Cancer Center Research Institute) ,  Sakamoto Hiromi (Fundamental Innovative Oncology Core, National Cancer Center Research Institute) ,  Kato Ken (Department of Gastrointestinal Medical Oncology, National Cancer Center Hospital) ,  Mushiroda Taisei (RIKEN, Center for Integrative Medical Sciences) ,  Tsugawa Koichiro (Division of Breast and Endocrine Surgery, Department of Surgery, St.Marianna University School of Medicine) ,  Zembutsu Hitoshi (Project for Development of Liquid Biopsy Diagnosis, Japanese Foundation for Cancer Research, Research Institute) ,  Zembutsu Hitoshi (Fundamental Innovative Oncology Core, National Cancer Center Research Institute)
Material： Biological and Pharmaceutical Bulletin (Web)
Volume： 42  Issue： 12  Page： 2045-2053(J-STAGE)  Publication year： 2019 
JST Material Number： U1402A  ISSN： 1347-5215  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： human ,...
Semi thesaurus term： Trastuzumab ,...

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Author keywords (10)： cardiotoxicity ,  human epidermal growth factor receptor 2 (HER2) ,  breast cancer ,  trastuzumab ,  genome-wide association study (GWAS) ,  cardiotoxicity ,  human epidermal growth factor receptor 2 (HER2) ,  breast cancer ,  trastuzumab ,  genome-wide association study (GWAS)

JST classification (2)： Cardiovascular system diseases  (GJ03000C) ,  Poisoning in general  (GD06010Q)

Reference (42)：

• 1) Bonifazi M, Franchi M, Rossi M, Moja L, Zambelli A, Zambon AT, Corrao G, La Vecchia C, Zocchetti C, Negri E. Trastuzumab-related cardiotoxicity in early breast cancer: a cohort study. Oncologist, 18, 795-801 (2013).
• 2) Hsieh AC, Moasser MM. Targeting HER proteins in cancer therapy and the role of the non-target HER3. Br. J. Cancer, 97, 453-457 (2007).
• 3) Valabrega G, Montemurro F, Aglietta M. Trastuzumab: mechanism of action, resistance and future perspectives in HER2-overexpressing breast cancer. Ann. Oncol., 18, 977-984 (2007).
• 4) Pondé NF, Lambertini M, de Azambuja E. Twenty years of anti-HER2 therapy-associated cardiotoxicity. ESMO Open, 1, e000073 (2016).
• 5) Jones KL, Buzdar AU. Evolving novel anti-HER2 strategies. Lancet Oncol., 10, 1179-1187 (2009).

Terms in the title (9)： ゲノム ,  研究 ,  日本人 ,  集団 ,  トラスツズマブ ,  誘導 ,  心毒性 ,  遺伝マーカー ,  同定