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J-GLOBAL ID：202002275444793736   Reference number：20A0189220

Upregulation of IFN-β induced by Sema4D-dependent partial Erk1/2 inhibition promotes NO production in microglia

Sema4D依存性部分ERK1/2阻害により誘導されるIFN-βのアップレギュレーションはミクログリアにおけるNO産生を促進する【JST・京大機械翻訳】

Author (15)： Tsuchihashi Ryo (Group of Neurobiology, Division of Health Sciences, Graduate School of Medicine, Osaka University, Suita, Japan) ,  Sawano Toshinori (Group of Neurobiology, Division of Health Sciences, Graduate School of Medicine, Osaka University, Suita, Japan) ,  Sawano Toshinori (Laboratory of Pharmacology, Department of Biomedical Sciences, College of Life Sciences, Ritsumeikan University, Kusatsu, Japan) ,  Watanabe Fumiya (Group of Neurobiology, Division of Health Sciences, Graduate School of Medicine, Osaka University, Suita, Japan) ,  Yamaguchi Natsumi (Laboratory of Pharmacology, Department of Biomedical Sciences, College of Life Sciences, Ritsumeikan University, Kusatsu, Japan) ,  Yamaguchi Wataru (Kagawa Prefectural College of Health Sciences, Takamatsu, Japan) ,  Niimi Kenta (Group of Neurobiology, Division of Health Sciences, Graduate School of Medicine, Osaka University, Suita, Japan) ,  Niimi Kenta (Kagawa Prefectural College of Health Sciences, Takamatsu, Japan) ,  Shibata Satoshi (Group of Neurobiology, Division of Health Sciences, Graduate School of Medicine, Osaka University, Suita, Japan) ,  Shibata Satoshi (Department of Molecular Pathology, Division of Health Sciences, Graduate School of Medicine, Osaka University, Suita, Japan) ,  Furuyama Tatsuo (Kagawa Prefectural College of Health Sciences, Takamatsu, Japan) ,  Tanaka Hidekazu (Laboratory of Pharmacology, Department of Biomedical Sciences, College of Life Sciences, Ritsumeikan University, Kusatsu, Japan) ,  Inagaki Shinobu (Group of Neurobiology, Division of Health Sciences, Graduate School of Medicine, Osaka University, Suita, Japan) ,  Inagaki Shinobu (United Graduate School of Child Development, Osaka University, Suita, Japan) ,  Inagaki Shinobu (Department of Physical Therapy, Osaka Yukioka College of Health Science, Ibaraki, Japan)
Material： Biochemical and Biophysical Research Communications  (BBRC)
Volume： 521  Issue： 4  Page： 827-832  Publication year： 2020 
JST Material Number： B0118A  ISSN： 0006-291X  Document type： Article
Article type： 短報  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Interactions between Sema4D an...

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Thesaurus term： phosphorylation ,  receptor ,  cerebral ischemia ,  interaction ,  mRNA ,  nitrogen monoxide ,  ischemia ,  *Up-Regulation ,  *microglia ,  cortex ,  angiogenesis ,  Down-Regulation ,  immune activation ,  Axon Guidance ,  *Erk1/2

Author keywords (5)： Sema4D ,  Microglia ,  NO ,  Erk1/2 ,  IFN-β

JST classification (2)： Gene expression  (EC02040Q) ,  Cell physiology in general  (EF02010S)

Terms in the title (10)： Sema4D ,  依存性 ,  ERK1 ,  阻害 ,  誘導 ,  IFN ,  アップレギュレーション ,  ミクログリア ,  NO ,  促進