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J-GLOBAL ID：202002275456956421   Reference number：20A1097824

WNT/β-catenin signal inhibitor IC-2-derived small-molecule compounds suppress TGF-β1-induced fibrogenic response of renal epithelial cells by inhibiting SMAD2/3 signalling

Wnt/β-カテニンシグナル阻害剤IC-2由来小分子化合物はSmad2/3シグナル伝達阻害により腎臓上皮細胞のTGF-β1誘導線維形成応答を抑制する【JST・京大機械翻訳】

Author (10)： Hoi Shotaro (Division of Molecular and Genetic Medicine, Graduate School of Medicine, Tottori University, Yonago, Japan) ,  Hoi Shotaro (Division of Medicine and Clinical Science, Faculty of Medicine, Tottori University, Yonago, Japan) ,  Tsuchiya Hiroyuki (Division of Molecular and Genetic Medicine, Graduate School of Medicine, Tottori University, Yonago, Japan) ,  Itaba Noriko (Division of Molecular and Genetic Medicine, Graduate School of Medicine, Tottori University, Yonago, Japan) ,  Suzuki Kyosuke (Division of Molecular and Genetic Medicine, Graduate School of Medicine, Tottori University, Yonago, Japan) ,  Oka Hiroyuki (Research Center for Bioscience and Technology, Tottori University, Tottori, Japan) ,  Morimoto Minoru (Research Center for Bioscience and Technology, Tottori University, Tottori, Japan) ,  Takata Tomoaki (Division of Medicine and Clinical Science, Faculty of Medicine, Tottori University, Yonago, Japan) ,  Isomoto Hajime (Division of Medicine and Clinical Science, Faculty of Medicine, Tottori University, Yonago, Japan) ,  Shiota Goshi (Division of Molecular and Genetic Medicine, Graduate School of Medicine, Tottori University, Yonago, Japan)
Material： Clinical and Experimental Pharmacology and Physiology  (Clin Exp Pharmacol Physiol)
Volume： 47  Issue： 6  Page： 940-946  Publication year： 2020 
JST Material Number： H0759A  ISSN： 0305-1870  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： Renal fibrosis compromises kid...

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Thesaurus term： *epithelium ,  kidney tubule ,  human ,  differentiation (biology) ,  phosphorylation ,  *fibrous disease ,  *TGF beta ,  risk factor ,  *catenin ,  Chronic kidney disease ,  *TGF-beta(1) ,  *beta Catenin ,  Epithelial-Mesenchymal Transition ,  *Signal Transduction ,  *membrane and film ,  *histomembrane ,  *Proteins
Semi thesaurus term： *cellular signal transduction ,  腎線維症 , 【Automatic Indexing@JST】

Author keywords (4)： renal fibrosis ,  TGF-β1/SMAD signalling ,  tubular epithelial cells ,  WNT/β-catenin inhibitor

JST classification (2)： Basic medicine on urogenital system  (GM01020T) ,  Basic research of drugs acting on urinary system  (GW11010R)

Terms in the title (14)： Wnt ,  β-カテニン ,  シグナル ,  阻害剤 ,  IC-2 ,  分子化合物 ,  Smad2 ,  シグナル伝達 ,  阻害 ,  腎臓上皮細胞 ,  TGF-β1 ,  誘導 ,  線維形成 ,  応答