Art

J-GLOBAL ID：202002275733759799   Reference number：20A1190311

Shimalactone Biosynthesis Involves Spontaneous Double Bicyclo-Ring Formation with 8π-6π Electrocyclization

シマラクトン生合成は8π-6π電子環化による自発的二重ビシクロ環形成を含む【JST・京大機械翻訳】

Author (27)： Fujii Isao (Division of Natural Product Sciences, School of Pharmacy, Iwate Medical University, 1-1-1 Idaidori, Yahaba, Iwate, 028-3694, Japan) ,  Hashimoto Makoto (Division of Natural Product Sciences, School of Pharmacy, Iwate Medical University, 1-1-1 Idaidori, Yahaba, Iwate, 028-3694, Japan) ,  Hashimoto Makoto (Current address: Research Institute of Pharmaceutical Sciences, Musashino University, 1-1-20 Shinmachi, Nishitokyo-shi, Tokyo, 202-8585, Japan) ,  Konishi Kaori (Division of Natural Product Sciences, School of Pharmacy, Iwate Medical University, 1-1-1 Idaidori, Yahaba, Iwate, 028-3694, Japan) ,  Unezawa Akiko (Division of Natural Product Sciences, School of Pharmacy, Iwate Medical University, 1-1-1 Idaidori, Yahaba, Iwate, 028-3694, Japan) ,  Sakuraba Haruka (Division of Natural Product Sciences, School of Pharmacy, Iwate Medical University, 1-1-1 Idaidori, Yahaba, Iwate, 028-3694, Japan) ,  Suzuki Kenta (Division of Natural Product Sciences, School of Pharmacy, Iwate Medical University, 1-1-1 Idaidori, Yahaba, Iwate, 028-3694, Japan) ,  Tsushima Harue (Division of Natural Product Sciences, School of Pharmacy, Iwate Medical University, 1-1-1 Idaidori, Yahaba, Iwate, 028-3694, Japan) ,  Iwasaki Miho (Division of Natural Product Sciences, School of Pharmacy, Iwate Medical University, 1-1-1 Idaidori, Yahaba, Iwate, 028-3694, Japan) ,  Yoshida Satsuki (Division of Natural Product Sciences, School of Pharmacy, Iwate Medical University, 1-1-1 Idaidori, Yahaba, Iwate, 028-3694, Japan) ,  Kudo Akane (Division of Natural Product Sciences, School of Pharmacy, Iwate Medical University, 1-1-1 Idaidori, Yahaba, Iwate, 028-3694, Japan) ,  Fujita Rina (Division of Natural Product Sciences, School of Pharmacy, Iwate Medical University, 1-1-1 Idaidori, Yahaba, Iwate, 028-3694, Japan) ,  Hichiwa Aika (Division of Natural Product Sciences, School of Pharmacy, Iwate Medical University, 1-1-1 Idaidori, Yahaba, Iwate, 028-3694, Japan) ,  Saito Koharu (Division of Natural Product Sciences, School of Pharmacy, Iwate Medical University, 1-1-1 Idaidori, Yahaba, Iwate, 028-3694, Japan) ,  Asano Takashi (Division of Natural Product Sciences, School of Pharmacy, Iwate Medical University, 1-1-1 Idaidori, Yahaba, Iwate, 028-3694, Japan) ,  Ishikawa Jun (Department of Bioactive Molecules, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo, 162-8640, Japan) ,  Wakana Daigo (National Institute of Health Sciences, 3-25-26 Tonomachi, Kawasaki-ku, Kanagawa, 210-9501, Japan) ,  Wakana Daigo (Current address: Department of Organic Chemistry, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo, 142-8501, Japan) ,  Goda Yukihiro (National Institute of Health Sciences, 3-25-26 Tonomachi, Kawasaki-ku, Kanagawa, 210-9501, Japan) ,  Watanabe Ayumi (Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan) ,  Watanabe Mamoru (Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan) ,  Masumoto Yui (Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan) ,  Kanazawa Junichiro (Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan) ,  Sato Hajime (Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan) ,  Sato Hajime (Cluster for Pioneering Research (CPR), Advanced Elements Chemistry Laboratory, RIKEN, 2-1 Hirosawa, Wako-shi, Saitama, 351-0198, Japan) ,  Uchiyama Masanobu (Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan) ,  Uchiyama Masanobu (Cluster for Pioneering Research (CPR), Advanced Elements Chemistry Laboratory, RIKEN, 2-1 Hirosawa, Wako-shi, Saitama, 351-0198, Japan)
Material： Angewandte Chemie. International Edition  (Angewandte Chemie. International Edition in English)
Volume： 59  Issue： 22  Page： 8464-8470  Publication year： 2020 
JST Material Number： H0127B  ISSN： 1433-7851  CODEN： ACIEAY  Document type： Article
Article type： 原著論文  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Abstract/Point： Shimalactones A and B are neur...

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Thesaurus term： enzyme ,  *biosynthesis ,  protonation ,  ocean ,  ring-opening reaction ,  Eumycetes ,  *cyclization reaction ,  Aspergillus oryzae ,  Saccharomyces cerevisiae ,  density functional method ,  in vitro experiment
Semi thesaurus term： ポリケチドシンターゼ ,  ポリケチド類 ,  遺伝子クラスタ ,  異種発現 , 【Automatic Indexing@JST】

Author keywords (5)： biosynthesis ,  electrocyclization ,  oxabicyclo rings ,  polyketides ,  shimalactone

JST classification (2)： Synthesis of antibiotics  (GX04000Z) ,  Enzyme in general  (EB09010D)

Terms in the title (5)： 生合成 ,  π ,  π電子 ,  環化 ,  環形成