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J-GLOBAL ID：202002276041211278   Reference number：20A0254366

Gold nanoparticle-adjuvanted S protein induces a strong antigen-specific IgG response against severe acute respiratory syndrome-related coronavirus infection, but fails to induce protective antibodies and limit eosinophilic infiltration in lungs

金ナノ粒子アジュバントS蛋白質は重症急性呼吸器症候群関連コロナウイルス感染症に対する強い抗原特異的IgG応答を誘導するが,防御抗体を誘導できず,肺における好酸球浸潤を制限できない

Author (11)： Sekimukai Hanako (Department of Pathology, National Institute of Infectious Diseases, Musashimurayama, Tokyo, Japan) ,  Sekimukai Hanako (Department of Tissue Physiology, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Fuchu, Tokyo, Japan) ,  Iwata-Yoshikawa Naoko (Department of Pathology, National Institute of Infectious Diseases, Musashimurayama, Tokyo, Japan) ,  Fukushi Shuetsu (Department of Virology I, National Institute of Infectious Diseases, Musashimurayama, Tokyo, Japan) ,  Tani Hideki (Department of Virology I, National Institute of Infectious Diseases, Musashimurayama, Tokyo, Japan) ,  Kataoka Michiyo (Department of Pathology, National Institute of Infectious Diseases, Musashimurayama, Tokyo, Japan) ,  Suzuki Tadaki (Department of Pathology, National Institute of Infectious Diseases, Musashimurayama, Tokyo, Japan) ,  Hasegawa Hideki (Department of Pathology, National Institute of Infectious Diseases, Musashimurayama, Tokyo, Japan) ,  Niikura Kenichi (Research Institute for Electronic Science, Hokkaido University, Sapporo, Hokkaido, Japan) ,  Arai Katsuhiko (Department of Tissue Physiology, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Fuchu, Tokyo, Japan) ,  Nagata Noriyo (Department of Pathology, National Institute of Infectious Diseases, Musashimurayama, Tokyo, Japan)
Material： Microbiology and Immunology  (Microbiol Immunol)
Volume： 64  Issue： 1  Page： 33-51  Publication year： Jan. 2020 
JST Material Number： W1957A  ISSN： 0385-5600  Document type： Article
Article type： 原著論文  Country of issue： Australia (AUS)  Language： ENGLISH (EN)

Thesaurus term： viral disease ,...
Semi thesaurus term： Coronavirus Infections ,...

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Author keywords (6)： adjuvant ,  coronavirus ,  eosinophils ,  gold nanoparticles ,  immunopathology ,  mouse model

JST classification (3)： Basic research of immunotherapeutic agents and blood preparations  (GW22010D) ,  Infectious immunity  (ED03030P) ,  Production and application of antigens,antibodies,complements  (ED04030W)

Terms in the title (14)： 金ナノ粒子 ,  アジュバント ,  S蛋白質 ,  重症急性呼吸器症候群 ,  コロナウイルス感染症 ,  抗原 ,  IgG ,  応答 ,  誘導 ,  防御抗体 ,  きず ,  肺 ,  好酸球浸潤 ,  制限