Art

J-GLOBAL ID：202002277141505930   Reference number：20A0824422

A key mammalian cholesterol synthesis enzyme, squalene monooxygenase, is allosterically stabilized by its substrate

重要な哺乳類コレステロール合成酵素,スクアレンモノオキシゲナーゼはその基質によりアロステリックに安定化される【JST・京大機械翻訳】

Author (7)： Yoshioka Hiromasa (aInstitute for Quantitative Biosciences, The University of Tokyo, 113-0032 Tokyo, Japan;) ,  Coates Hudson W. (bSchool of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia;) ,  Chua Ngee Kiat (bSchool of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia;) ,  Hashimoto Yuichi (aInstitute for Quantitative Biosciences, The University of Tokyo, 113-0032 Tokyo, Japan;) ,  Brown Andrew J. (bSchool of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia;) ,  Ohgane Kenji (aInstitute for Quantitative Biosciences, The University of Tokyo, 113-0032 Tokyo, Japan;) ,  Ohgane Kenji (cSynthetic Organic Chemistry Laboratory, RIKEN, 351-0198 Saitama, Japan)
Material： Proceedings of the National Academy of Sciences of the United States of America  (PNAS)
Volume： 117  Issue： 13  Page： 7150-7158  Publication year： 2020 
JST Material Number： D0387A  ISSN： 0027-8424  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： Cholesterol biosynthesis is a ...

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Thesaurus term： *enzyme ,  feedforward ,  interaction ,  robustness ,  *substrate(biochemistry) ,  epoxidation ,  up-regulation ,  rate-limiting ,  *Mammalia ,  negative feedback ,  ubiquitination ,  luciferase ,  photoaffinity labeling ,  sterol ,  alicyclic alcohol ,  polyene ,  linear triterpene

Author keywords (4)： squalene ,  squalene monooxygenase ,  chemical genetics ,  cholesterol homeostasis

JST classification (5)： Metabolic diseases,nutritional diseases in general.  (GD05010J) ,  Biological function  (EB05020M) ,  Central nervous system  (EJ12030F) ,  Metabolism and nutrition  (EG03054K) ,  Cell physiology in general  (EF02010S)

Substance index (2)： Cholesterol ,  Squalene

Terms in the title (6)： 哺乳類 ,  コレステロール ,  合成酵素 ,  スクアレンモノオキシゲナーゼ ,  基質 ,  安定化