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J-GLOBAL ID：202002277552188283   Reference number：20A1517354

Pharmacokinetics of single dose sildenafil orally administered in canine models of chronic embolic pulmonary hypertension

慢性塞栓性肺高血圧症のイヌモデルに経口投与した単回投与シルデナフィルの薬物動態

Author (9)： AKABANE Ryota (Laboratory of Veterinary Internal Medicine II, School of Veterinary Medicine, Nippon Veterinary and Life Science University, 1-7-1 Kyonan-cho, Musashino-shi, Tokyo 180-8602, Japan) ,  SATO Touko (Laboratory of Biomolecular Chemistry, School of Veterinary Medicine, Nippon Veterinary and Life Science University, 1-7-1 Kyonan-cho, Musashino-shi, Tokyo 180-8602, Japan) ,  SAKATANI Atsushi (Laboratory of Veterinary Internal Medicine II, School of Veterinary Medicine, Nippon Veterinary and Life Science University, 1-7-1 Kyonan-cho, Musashino-shi, Tokyo 180-8602, Japan) ,  OGAWA Mizuki (Laboratory of Veterinary Internal Medicine II, School of Veterinary Medicine, Nippon Veterinary and Life Science University, 1-7-1 Kyonan-cho, Musashino-shi, Tokyo 180-8602, Japan) ,  NAGAKAWA Masayoshi (Laboratory of Veterinary Internal Medicine II, School of Veterinary Medicine, Nippon Veterinary and Life Science University, 1-7-1 Kyonan-cho, Musashino-shi, Tokyo 180-8602, Japan) ,  MIYAKAWA Hirosumi (Laboratory of Veterinary Internal Medicine II, School of Veterinary Medicine, Nippon Veterinary and Life Science University, 1-7-1 Kyonan-cho, Musashino-shi, Tokyo 180-8602, Japan) ,  MIYAGAWA Yuichi (Laboratory of Veterinary Internal Medicine II, School of Veterinary Medicine, Nippon Veterinary and Life Science University, 1-7-1 Kyonan-cho, Musashino-shi, Tokyo 180-8602, Japan) ,  TAZAKI Hiroyuki (Laboratory of Biomolecular Chemistry, School of Veterinary Medicine, Nippon Veterinary and Life Science University, 1-7-1 Kyonan-cho, Musashino-shi, Tokyo 180-8602, Japan) ,  TAKEMURA Naoyuki (Laboratory of Veterinary Internal Medicine II, School of Veterinary Medicine, Nippon Veterinary and Life Science University, 1-7-1 Kyonan-cho, Musashino-shi, Tokyo 180-8602, Japan)
Material： Journal of Veterinary Medical Science (Web)
Volume： 82  Issue： 4  Page： 446-451(J-STAGE)  Publication year： 2020 
JST Material Number： U1094A  ISSN： 1347-7439  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *Thromboembolism ,...
Semi thesaurus term： PDE5inhibitor ,...

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Author keywords (5)： dog ,  microsphere ,  pharmacokinetics ,  pulmonary hypertension ,  sildenafil

JST classification (3)： Other animal diseases  (FE02060T) ,  Medical pharmaceuticals for animals  (FE01050B) ,  Basic medicine on cardiovascular system  (GJ01020K)

Substance index (1)： Sildenafil

Reference (29)：

• 1. Akabane, R., Sato, T., Sakatani, A., Miyagawa, Y., Tazaki, H. and Takemura, N. 2018. Pharmacokinetics of single-dose sildenafil administered orally in clinically healthy dogs: Effect of feeding and dose proportionality. J. Vet. Pharmacol. Ther. 41: 457-462.
• 2. Al-Mohizea, A. M., Ahad, A., El-Maghraby, G. M., Al-Jenoobi, F. I., AlKharfy, K. M. and Al-Suwayeh, S. A. 2015. Effects of Nigella sativa, Lepidium sativum and Trigonella foenum-graecum on sildenafil disposition in beagle dogs. Eur. J. Drug Metab. Pharmacokinet. 40: 219-224.
• 3. Bach, J. F., Rozanski, E. A., MacGregor, J., Betkowski, J. M. and Rush, J. E. 2006. Retrospective evaluation of sildenafil citrate as a therapy for pulmonary hypertension in dogs. J. Vet. Intern. Med. 20: 1132-1135.
• 4. Borgarelli, M., Abbott, J., Braz-Ruivo, L., Chiavegato, D., Crosara, S., Lamb, K., Ljungvall, I., Poggi, M., Santilli, R. A. and Haggstrom, J. 2015. Prevalence and prognostic importance of pulmonary hypertension in dogs with myxomatous mitral valve disease. J. Vet. Intern. Med. 29: 569-574.
• 5. Brown, A. J., Davison, E. and Sleeper, M. M. 2010. Clinical efficacy of sildenafil in treatment of pulmonary arterial hypertension in dogs. J. Vet. Intern. Med. 24: 850-854.

Terms in the title (9)： 慢性 ,  塞栓 ,  肺高血圧症 ,  イヌ ,  モデル ,  経口投与 ,  単回投与 ,  シルデナフィル ,  薬物動態