Art

J-GLOBAL ID：202002277937402651   Reference number：20A1531964

Total Syntheses and Cytotoxic Evaluations of Cryptolactones A₁, A₂, B₁, B₂, and Their Derivatives

クリプトラクトンA₁,A₂,B₁,B₂およびそれらの誘導体の全合成および細胞毒性評価

Author (7)： Inai Makoto (School of Pharmaceutical Sciences, University of Shizuoka) ,  Oguri Yuki (Faculty of Pharmaceutical Sciences, Tokushima Bunri University) ,  Horikawa Mitsuyo (Faculty of Pharmaceutical Sciences, Tokushima Bunri University) ,  Kaku Hiroto (Faculty of Pharmaceutical Sciences, Tokushima Bunri University) ,  Suzuki Shinya (Faculty of Pharmaceutical Sciences, Tokushima Bunri University) ,  Kitamura Kei (Faculty of Pharmaceutical Sciences, Tokushima Bunri University) ,  Tsunoda Tetsuto (Faculty of Pharmaceutical Sciences, Tokushima Bunri University)
Material： Chemical and Pharmaceutical Bulletin (Web)
Volume： 68  Issue： 4  Page： 380-383(J-STAGE)  Publication year： 2020 
JST Material Number： U1401A  ISSN： 1347-5223  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *lactone ,...
Semi thesaurus term： Cryptomyzus ,...

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Author keywords (6)： cryptolactones ,  asymmetric synthesis ,  cytotoxicity ,  cryptolactones ,  asymmetric synthesis ,  cytotoxicity

JST classification (2)： Other natural substances of biological origin  (CF10090R) ,  Basic research of antitumor(=antineoplastic)drugs  (GW16010A)

Substance index (12)： (6R)-6-[(2R)-2-hydroxy-4-oxodecyl]-5,6-dihydropyran-2-one ,  (6R)-6-[(2R)-2-hydroxy-4-oxotetradecyl]-5,6-dihydropyran-2-one ,  (6R)-6-[(2R)-2-hydroxy-4-oxododecyl]-5,6-dihydropyran-2-one ,  (6R)-6-[(2S)-2-hydroxy-4-oxodecyl]-5,6-dihydropyran-2-one ,  (6R)-6-[(2S)-2-hydroxy-4-oxotetradecyl]-5,6-dihydropyran-2-one ,  (6R)-6-[(2S)-2-hydroxy-4-oxododecyl]-5,6-dihydropyran-2-one ,  (6S)-6-[(2R)-2-hydroxy-4-oxodecyl]-5,6-dihydropyran-2-one ,  (6S)-6-[(2S)-2-hydroxy-4-oxodecyl]-5,6-dihydropyran-2-one ,  Cryptolactone A₁ ,  Cryptolactone A₂ ,  Cryptolactone B₁ ,  Cryptolactone B₂

Reference (21)：

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• 2) Horikawa M., Tanaka M., Kaku H., Nishii T., Tsunoda T., Tetrahedron, 64, 5515-5518 (2008).
• 3) Horikawa M., Hoshiyama T.-S., Matsuzawa M., Shugyo T., Tanaka M., Suzuki S., Sato M., Ito T., Asakawa Y., Kaku H., Nishii T., Inai M., Takahashi S., Tsunoda T., J. Nat. Prod., 74, 1812-1816 (2011).
• 4) Horikawa M., Noguchi T., Takaoka S., Kawase M., Sato M., Tsunoda T., Tetrahedron, 60, 1229-1234 (2004).
• 5) Horikawa M., Kikuchi D., Imai T., Tanaka M., Kaku H., Nishii T., Inai M., Takahashi S., Tsunoda T., Heterocycles, 85, 95-101 (2012).

Terms in the title (4)： 誘導体 ,  全合成 ,  細胞毒性 ,  評価