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J-GLOBAL ID：202002278108593166   Reference number：20A2578500

Amino Acid Transporter SLC6A14 (ATB^0,+) - A Target in Combined Anti-cancer Therapy

アミノ酸輸送体SLC6A14(ATB=0,+) 併用抗癌療法における標的【JST・京大機械翻訳】

Author (1)： Nalecz Katarzyna A. (Laboratory of Transport Through Biomembranes, Nencki Institute of Experimental Biology, Warsaw, Poland)
Material： Frontiers in Cell and Developmental Biology (Web)
Volume： 8  Page： 594464  Publication year： 2020 
JST Material Number： U7062A  ISSN： 2296-634X  Document type： Article
Article type： 文献レビュー  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： Cancer cells are characterized...

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Thesaurus term： interaction ,  *amino acid ,  nutrient ,  tumor cell ,  phosphorylation ,  folding(morphology) ,  cargo ,  subunit ,  solute ,  prognosis ,  targeting ,  pancreatic tumor ,  breast tumor
Semi thesaurus term： *輸送体 ,  *癌治療 , 【Automatic Indexing@JST】

Author keywords (7)： amino acid transporter ,  cancer ,  SLC6A14 ,  estrogen receptor ,  trafficking ,  heat shock proteins ,  AKT 3

JST classification (1)： Transport of cell membrane  (EF04020R)

Reference (148)：

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• AltomareD. A.TestaJ. R. (2005). Perturbations of the AKT signaling pathway in human cancer. Oncogene 24 7455-7464. doi: 10.1038/sj.onc.1209085 16288292
• AndersonC. M.GanapathyV.ThwaitesD. T. (2008). Human solute carrier SLC6A14 is the beta-alanine carrier. J. Physiol. 586 4061-4067. doi: 10.1113/jphysiol.2008.154500 18599538
• BabuE.BhutiaY. D.RamachandranS.GnanaprakasamJ. P.PrasadP. D.ThangarajuM. (2015). Deletion of the amino acid transporter Slc6a14 suppresses tumour growth in spontaneous mouse models of breast cancer. Biochem. J. 469 17-23. doi: 10.1042/BJ20150437 26173258
• BacciM.LoritoN.IppolitoL.RamazzottiM.LutiS.RomagnoliS. (2019). Reprogramming of amino acid transporters to support aspartate and glutamate dependency sustains endocrine resistance in Breast Cancer. Cell Rep. 28 104.e8-118.e8. doi: 10.1016/j.celrep.2019.06.010 31269432

Terms in the title (4)： アミノ酸輸送体 ,  併用 ,  抗癌療法 ,  標的