Art

J-GLOBAL ID：202002278131665482   Reference number：20A2536574

A G-quadruplex-forming RNA aptamer binds to the MTG8 TAFH domain and dissociates the leukemic AML1-MTG8 fusion protein from DNA

G四重鎖形成RNAアプタマーはMTG8 TAFHドメインに結合し,DNAから白血病AML1-MTG8融合蛋白質を解離する【JST・京大機械翻訳】

Author (10)： Fukunaga Junichi (Research Institute for Clinical Oncology, Saitama Cancer Center, Ina, Japan) ,  Nomura Yusuke (Department of Life and Environmental Sciences, Faculty of Engineering, Chiba Institute of Technology, Narashino, Japan) ,  Nomura Yusuke (Department of Applied Chemistry, Faculty of Science, Tokyo University of Science, Shinjuku-ku, Japan) ,  Tanaka Yoichiro (Research Institute for Clinical Oncology, Saitama Cancer Center, Ina, Japan) ,  Tanaka Yoichiro (Facility for RI Research and Education, Instrumental Analysis Center, Research Initiatives and Promotion Organization, Yokohama National University, Hodogaya-ku, Japan) ,  Torigoe Hidetaka (Department of Applied Chemistry, Faculty of Science, Tokyo University of Science, Shinjuku-ku, Japan) ,  Nakamura Yoshikazu (Department of Basic Medical Sciences, Institute of Medical Science, University of Tokyo, Minato-ku, Japan) ,  Nakamura Yoshikazu (Ribomic Inc., Minato-ku, Japan) ,  Sakamoto Taiichi (Department of Life and Environmental Sciences, Faculty of Engineering, Chiba Institute of Technology, Narashino, Japan) ,  Kozu Tomoko (Research Institute for Clinical Oncology, Saitama Cancer Center, Ina, Japan)
Material： FEBS Letters  (for the Rapid Publication of Short Reports in Biochemistry, Biophysics)
Volume： 594  Issue： 21  Page： 3477-3489  Publication year： 2020 
JST Material Number： D0575A  ISSN： 0014-5793  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： MTG8 (RUNX1T1) is a fusion par...

Register(free) or Log In to access     To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=20A2536574&from=J-GLOBAL&jstjournalNo=D0575A") }}

Thesaurus term： NMR ,  *DNA ,  *Leukemia ,  human ,  Chimera ,  complex (substance) ,  mutagenesis ,  *heavy chain ,  *fusion protein ,  *domain structure ,  *RNA aptamer ,  *aptamer ,  Runx1 ,  *AML1 ,  *G-Quadruplexes

Author keywords (5)： aptamer ,  G-quadruplex ,  leukemic ,  MTG8 ,  TAF

JST classification (1)： Biological function  (EB03040U)

Terms in the title (8)： G四重鎖 ,  RNAアプタマー ,  ドメイン ,  DNA ,  白血病 ,  AML1 ,  融合蛋白質 ,  解離