Art

J-GLOBAL ID：202002280637023624   Reference number：20A1199056

Application of a fluorous derivatization method for characterization of glutathione-trapped reactive metabolites with liquid chromatography-tandem mass spectrometry analysis

液体クロマトグラフィー-タンデム質量分析によるグルタチオン捕捉反応性代謝産物の特性化のためのフルオラス誘導体化法の応用【JST・京大機械翻訳】

Author (5)： Nishijo Nao (Faculty of Pharmaceutical Sciences, Fukuoka University, 8-19-1 Nanakuma, Johnan, Fukuoka 814-0180, Japan) ,  Hayama Tadashi (Faculty of Pharmaceutical Sciences, Fukuoka University, 8-19-1 Nanakuma, Johnan, Fukuoka 814-0180, Japan) ,  Tomita Ryoko (Faculty of Pharmaceutical Sciences, Fukuoka University, 8-19-1 Nanakuma, Johnan, Fukuoka 814-0180, Japan) ,  Yamaguchi Masatoshi (Faculty of Pharmaceutical Sciences, Fukuoka University, 8-19-1 Nanakuma, Johnan, Fukuoka 814-0180, Japan) ,  Fujioka Toshihiro (Faculty of Pharmaceutical Sciences, Fukuoka University, 8-19-1 Nanakuma, Johnan, Fukuoka 814-0180, Japan)
Material： Journal of Chromatography A  (J Chromatogr A)
Volume： 1622  Page： Null  Publication year： 2020 
JST Material Number： C0278B  ISSN： 0021-9673  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： The glutathione (GSH) trapping...

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Thesaurus term： ion ,  interaction ,  *metabolite ,  drug metabolism ,  *capture ,  stationary phase ,  affinity ,  precursor (substance) ,  *derivatization ,  incubate ,  *liquid chromatography-tandem mass spectrometry ,  trapping ,  aliphatic amine ,  thiol ,  aliphatic carboxylic acid ,  tripeptide ,  sulfur containing amino acid ,  adenine nucleotide ,  nicotinamide mononucleotide ,  nitrogen heterocyclic compound ,  oxygen heterocyclic compound
Semi thesaurus term： *LC/MS/MS ,  トラッピング , 【Automatic Indexing@JST】

Author keywords (5)： Reactive metabolite ,  Glutathione ,  Fluorous derivatization ,  Oxazolone chemistry ,  LC-MS/MS

JST classification (1)： Miscellaneous analytical methods of organic compounds  (CC08034J)

Substance index (3)： Glutathione ,  NADPH ,  Oxazolone

Terms in the title (8)： 液体クロマトグラフィー-タンデム質量分析 ,  グルタチオン ,  捕捉 ,  反応性 ,  代謝産物 ,  特性化 ,  誘導体化 ,  応用