Art

J-GLOBAL ID：202002280933426423   Reference number：20A0762154

V-ATPase a3 isoform mutations identified in osteopetrosis patients abolish its expression and disrupt osteoclast function

骨減少症患者において同定されたV-ATPアーゼA3アイソフォーム変異はその発現を消失させ破骨細胞機能を破壊する【JST・京大機械翻訳】

Author (7)： Matsumoto Naomi (Division of Biochemistry, School of Pharmacy, Iwate Medical University, Yahaba, Iwate, 028-3694, Japan) ,  Matsukawa Reina (Division of Biochemistry, School of Pharmacy, Iwate Medical University, Yahaba, Iwate, 028-3694, Japan) ,  Takahashi Shohei (Division of Biochemistry, School of Pharmacy, Iwate Medical University, Yahaba, Iwate, 028-3694, Japan) ,  Kudo Koshi (Division of Biochemistry, School of Pharmacy, Iwate Medical University, Yahaba, Iwate, 028-3694, Japan) ,  Sun-Wada Ge-Hong (Department of Biochemistry, Faculty of Pharmaceutical Sciences, Doshisha Women’s College, Kyotanabe, Kyoto, 610-0395, Japan) ,  Wada Yoh (Division of Biological Sciences, Institute of Scientific and Industrial Research, Osaka University, Ibaraki, Osaka, 567-0047, Japan) ,  Nakanishi-Matsui Mayumi (Division of Biochemistry, School of Pharmacy, Iwate Medical University, Yahaba, Iwate, 028-3694, Japan)
Material： Experimental Cell Research  (Exp Cell Res)
Volume： 389  Issue： 2  Page： Null  Publication year： 2020 
JST Material Number： B0313A  ISSN： 0014-4827  CODEN： ECREAL  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： The a3 isoform of vacuolar-typ...

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Thesaurus term： interaction ,  *ATPase ,  vacuole ,  Mutation ,  spleen ,  human ,  child ,  lysosome ,  macrophage ,  Bone Resorption ,  *osteoclast ,  wild type ,  in vitro experiment ,  missense mutation ,  knockout mouse ,  laboratory animal ,  Mus musculus

Author keywords (6)： V-ATPase ,  a3 isoform ,  Osteopetrosis mutation ,  Osteoclast ,  Lysosome ,  Rab7

JST classification (2)： Skeletal system  (EJ10030R) ,  Cell physiology in general  (EF02010S)

Terms in the title (9)： 骨減少症 ,  患者 ,  同定 ,  V-ATPアーゼ ,  アイソフォーム ,  変異 ,  発現 ,  破骨細胞 ,  破壊