Art

J-GLOBAL ID：202002281243681597   Reference number：20A1016541

Unveiling synapse pathology in spinal bulbar muscular atrophy by genome-wide transcriptome analysis of purified motor neurons derived from disease specific iPSCs

疾患特異的IPSC由来の精製運動ニューロンのゲノムワイドトランスクリプトーム解析による脊髄球筋萎縮症におけるシナプス病理学の解明【JST・京大機械翻訳】

Author (25)： Onodera Kazunari (Department of Neurology, Aichi Medical University School of Medicine, Nagakute, Japan) ,  Onodera Kazunari (Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan) ,  Shimojo Daisuke (Department of Neurology, Aichi Medical University School of Medicine, Nagakute, Japan) ,  Shimojo Daisuke (Department of Physiology, Keio University School of Medicine, Tokyo, Japan) ,  Ishihara Yasuharu (Department of Physiology, Keio University School of Medicine, Tokyo, Japan) ,  Yano Masato (Division of Neurobiology and Anatomy, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan) ,  Miya Fuyuki (Department of Medical Science Mathematics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan) ,  Miya Fuyuki (Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo, Japan) ,  Miya Fuyuki (Laboratory for Medical Science Mathematics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan) ,  Banno Haruhiko (Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan) ,  Kuzumaki Naoko (Department of Physiology, Keio University School of Medicine, Tokyo, Japan) ,  Kuzumaki Naoko (Department of Pharmacology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo, Japan) ,  Ito Takuji (Department of Neurology, Aichi Medical University School of Medicine, Nagakute, Japan) ,  Okada Rina (Department of Neurology, Aichi Medical University School of Medicine, Nagakute, Japan) ,  Herculano Bruno de Araujo (Department of Neurology, Aichi Medical University School of Medicine, Nagakute, Japan) ,  Ohyama Manabu (Department of Dermatology, Keio University School of Medicine, Tokyo, Japan) ,  Yoshida Mari (Department of Neuropathology, Institute for Medical Science of Aging, Aichi Medical University, Nagakute, Japan) ,  Tsunoda Tatsuhiko (Department of Medical Science Mathematics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan) ,  Tsunoda Tatsuhiko (Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo, Japan) ,  Tsunoda Tatsuhiko (Laboratory for Medical Science Mathematics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan) ,  Katsuno Masahisa (Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan) ,  Doyu Manabu (Department of Neurology, Aichi Medical University School of Medicine, Nagakute, Japan) ,  Sobue Gen (Research Division of Dementia and Neurodegenerative Disease, Nagoya University Graduate School of Medicine, Nagoya, Japan) ,  Okano Hideyuki (Department of Physiology, Keio University School of Medicine, Tokyo, Japan) ,  Okada Yohei (Department of Neurology, Aichi Medical University School of Medicine, Nagakute, Japan)
Material： Molecular Brain (Web)
Volume： 13  Issue： 1  Page： 1-15  Publication year： 2020 
JST Material Number： U7335A  ISSN： 1756-6606  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Abstract/Point： Spinal bulbar muscular atrophy...

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Thesaurus term： aggregation ,  RNA ,  gene ,  *motor nerve ,  cell culture ,  *synapse ,  *Spinal Cord ,  clustering ,  gene expression ,  *Muscular Atrophy ,  *pathological state ,  transgenic mouse ,  Up-Regulation ,  in vitro experiment ,  androgen receptor ,  modification ,  molecular genetic phenomenon

Author keywords (10)： Spinal bulbar muscular atrophy ,  Induced pluripotent stem cells ,  iPSC-derived motor neurons ,  RNA sequencing ,  Gene set enrichment analysis ,  Synapse ,  Neurotransmitter ,  Neuromuscular junctions ,  Epigenetics ,  Endoplasmic reticulum

JST classification (2)： Basic neurology  (GN01020W) ,  Nervous system diseases  (GN03000O)

Reference (64)：

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• J Neurosci; Disrupted transforming growth factor-beta signaling in spinal and bulbar muscular atrophy; M Katsuno, H Adachi, M Minamiyama, M Waza, H Doi, N Kondo; 30; 2010; 5702-5712; 10.1523/JNEUROSCI.0388-10.2010; citation_id=CR5

Terms in the title (10)： 疾患 ,  IPSC ,  精製 ,  運動ニューロン ,  ゲノム ,  トランスクリプトーム解析 ,  脊髄 ,  萎縮症 ,  シナプス ,  病理学