Art

J-GLOBAL ID：202002281691314707   Reference number：20A2650331

Genome-Wide Association Study in Asians Identifies Novel Loci for High Myopia and Highlights a Nervous System Role in Its Pathogenesis

アジア人におけるゲノムワイド関連研究は高近視の新規遺伝子座を同定し,その病因における神経系の役割を強調する【JST・京大機械翻訳】

Author (37)： Meguro Akira (Department of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, Yokohama, Japan) ,  Meguro Akira (Department of Advanced Medicine for Ocular Diseases, Yokohama City University Graduate School of Medicine, Yokohama, Japan) ,  Yamane Takahiro (Department of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, Yokohama, Japan) ,  Yamane Takahiro (Department of Advanced Medicine for Ocular Diseases, Yokohama City University Graduate School of Medicine, Yokohama, Japan) ,  Takeuchi Masaki (Department of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, Yokohama, Japan) ,  Takeuchi Masaki (Department of Advanced Medicine for Ocular Diseases, Yokohama City University Graduate School of Medicine, Yokohama, Japan) ,  Miyake Masahiro (Department of Ophthalmology and Visual Science, Kyoto University Graduate School of Medicine, Kyoto, Japan) ,  Fan Qiao (Centre for Quantitative Medicine, Duke-NUS Medical School, Singapore, Republic of Singapore) ,  Fan Qiao (Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Republic of Singapore) ,  Zhao Wanting (Centre for Quantitative Medicine, Duke-NUS Medical School, Singapore, Republic of Singapore) ,  Zhao Wanting (Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Republic of Singapore) ,  Wang I-Jong (Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan) ,  Mizuki Yuki (Department of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, Yokohama, Japan) ,  Yamada Norihiro (Department of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, Yokohama, Japan) ,  Nomura Naoko (Department of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, Yokohama, Japan) ,  Tsujikawa Akitaka (Department of Ophthalmology and Visual Science, Kyoto University Graduate School of Medicine, Kyoto, Japan) ,  Matsuda Fumihiko (Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan) ,  Hosoda Yoshikatsu (Department of Ophthalmology and Visual Science, Kyoto University Graduate School of Medicine, Kyoto, Japan) ,  Saw Seang-Mei (Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Republic of Singapore) ,  Saw Seang-Mei (Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Republic of Singapore) ,  Cheng Ching-Yu (Centre for Quantitative Medicine, Duke-NUS Medical School, Singapore, Republic of Singapore) ,  Cheng Ching-Yu (Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Republic of Singapore) ,  Cheng Ching-Yu (Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Republic of Singapore) ,  Cheng Ching-Yu (Ophthalmology & Visual Sciences Academic Clinical Program, Duke-NUS Medical School, Singapore, Republic of Singapore) ,  Tsai Tzu-Hsun (Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan) ,  Yoshida Masao (Department of Public Health, Kyorin University School of Medicine, Tokyo, Japan) ,  Iijima Yasuhito (Department of Ophthalmology, Aoto Eye Clinic, Yokohama, Japan) ,  Teshigawara Takeshi (Department of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, Yokohama, Japan) ,  Teshigawara Takeshi (Department of Advanced Medicine for Ocular Diseases, Yokohama City University Graduate School of Medicine, Yokohama, Japan) ,  Teshigawara Takeshi (Department of Ophthalmology, Yokosuka Chuoh Eye Clinic, Yokosuka, Japan) ,  Teshigawara Takeshi (Department of Ophthalmology, Tsurumi Chuoh Eye Clinic, Yokohama, Japan) ,  Okada Eiichi (Department of Ophthalmology, Okada Eye Clinic, Yokohama, Japan) ,  Ota Masao (Department of Advanced Medicine for Ocular Diseases, Yokohama City University Graduate School of Medicine, Yokohama, Japan) ,  Ota Masao (Department of Medicine, Division of Gastroenterology and Hepatology, Shinshu University School of Medicine, Matsumoto, Japan) ,  Inoko Hidetoshi (Department of Molecular Life Science, Division of Molecular Medical Science and Molecular Medicine, Tokai University School of Medicine, Isehara, Japan) ,  Mizuki Nobuhisa (Department of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, Yokohama, Japan) ,  Mizuki Nobuhisa (Department of Advanced Medicine for Ocular Diseases, Yokohama City University Graduate School of Medicine, Yokohama, Japan)
Material： Ophthalmology
Volume： 127  Issue： 12  Page： 1612-1624  Publication year： 2020 
JST Material Number： A1138A  ISSN： 0161-6420  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： To identify novel susceptibili...

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Thesaurus term： *Nervous System ,  *Heredity ,  *gene ,  synapse ,  Republic of Singapore ,  *Myopia ,  *pathogenesis ,  Ras protein ,  meta-analysis ,  annotation ,  single nucleotide polymorphism ,  Genome-Wide Association Study ,  Neurogenesis ,  susceptibility gene ,  Gene Ontology

JST classification (1)： Genetic variation  (EC01030Y)

Terms in the title (9)： アジア人 ,  ゲノム ,  研究 ,  近視 ,  遺伝子座 ,  同定 ,  病因 ,  神経系 ,  役割