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J-GLOBAL ID：202002282095463979   Reference number：20A0844079

Gene disruption of ribosomal protein L5 (RPL5) decreased the sensitivity of CHO-K1 cells to uncoupler carbonylcyanide-3-chlorophenylhydrazone

リボソーム蛋白質L5(RPL5)の遺伝子破壊は非結合性カルボニルシアニド-3-クロロフェニルヒドラゾンに対するCHO-K1細胞の感受性を低下させる

Author (6)： Araki Makoto (Meiji Pharmaceutical University, Tokyo, Japan.) ,  Ishibashi Takuya (Ritsumeikan-Global Innovation Research Organization, Ritsumeikan University, Kyoto, Japan.) ,  Munesue Masahiro (Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, Japan.) ,  Ohashi Kazuaki (School of Pharmacy, Iwate Medical University, Iwate, Japan.) ,  Nobukuni Yoshitaka (Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan.) ,  Maeda Masatomo (Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan.)
Material： Drug Discoveries & Therapeutics  (DD & T)
Volume： 13  Issue： 6  Page： 306-313(J-STAGE)  Publication year： 2019 
JST Material Number： F1177A  ISSN： 1881-7831  CODEN： DDTRBX  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *uncoupler ,...
Semi thesaurus term： *リボソーム蛋白質L5 ,...

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Author keywords (5)： Ribosomopathies ,  Diamond-Blackfan anemia ,  random gene trap mutagenesis ,  uncoupler ,  mitochondria

JST classification (2)： Function of cell components  (EF03060C) ,  Biological function  (EB03040U)

Substance index (1)： Carbonyl Cyanide m-Chlorophenyl Hydrazone

Reference (32)：

• 1. Kagawa Y, Cha SH, Hasegawa K, Hamamoto T, Endo H. Regulation of energy metabolism in human cells in aging and diabetes: FoF1, mtDNA, UCP, and ROS. Biochem Biophys Res Commun. 1999; 266:662-676.
• 2. Mitchell P. Keilin's respiratory chain concept and its chemiosmotic consequences. Science. 1979; 206:1148-1159.
• 3. Suomalainen A. Mitochondrial roles in disease: a box full of surprises. EMBO Mol Med. 2015; 7:1245-1247.
• 4. Angelini C, Bello L, Spinazzi M, Ferrati C. Mitochondrial disorders of the nuclear genome. Acta Myol. 2009; 28:16-23.
• 5. Terada H. Uncouplers of oxidative phosphorylation. Environ Health Perspect. 1990; 87:213-218.

Terms in the title (5)： リボソーム蛋白質 ,  遺伝子破壊 ,  結合性 ,  CHO-K1細胞 ,  感受性