Art

J-GLOBAL ID：202002282745109148   Reference number：20A0919542

The Reversible Salt Sensitivity Mediated through a Disparity of cGMP Signaling and the Therapeutic Application

細胞内サイクリックGMPのシグナル格差を介した食塩感受性の可逆性解明と治療応用

Author (1)： NAKAMURA TAISHI (熊本大 病院 医療情報経営企画部)
Material： ソルト・サイエンス研究財団助成研究報告集 2 医学 食品科学編  (ソルト・サイエンス研究財団助成研究報告集 2 医学・食品科学編)
Volume： 2018  Page： 111-118  Publication year： Mar. 2020 
JST Material Number： L7132A  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： JAPANESE (JA)

Thesaurus term： reaction control ,...
Semi thesaurus term： redox control ,...

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JST classification (8)： Food hygiene in general  (FJ01051H) ,  Seasonings,spices(=condiments)  (FJ10010W) ,  Circulation system in general  (EJ04010S) ,  Kidney  (EJ09030X) ,  Nervous system in general  (EJ12010J) ,  Enzyme physiology  (EJ02020P) ,  Gene expression  (EC02040Q) ,  Cell physiology in general  (EF02010S)

Substance index (1)： Aldosterone

Reference (15)：

• Morris RC Jr, Schmidlin O, Sebastian A, Tanaka M, Kurtz TW. Vasodysfunction that involves renal vasodysfunction, not abnormally increased renal retention of sodium, accounts for the initiation of salt-induced hypertension. Circulation. 2016 133(9):881-93
• Hall JE. Renal dysfunction, rather than nonrenal vascular dysfunction, mediates salt-induced hypertension. Circulation. 2016 133(9):894-907
• Kurtz TW, DiCarlo SE, Pravenec M, Morris RC. Changing views on the common physiologic abnormality that mediates salt sensitivity and initiation of salt-induced hypertension: Japanese research underpinning the vasodysfunction theory of salt sensitivity. Hypertens Res. 2019 42(1):6-18
• Nakamura T, Kataoka K, Tokutomi Y, Nako H, Toyama K, Dong YF, Koibuchi N, Yamamoto E, Yasuda O, Ogawa H, Kim-Mitsuyama S. Novel mechanism os salt-induced glomerular injury: critical role of eNOS and angiotensin II. J Hypertens. 2011 29(8):1528-35
• Kopkan L, Hess A, Huskova Z, Cervenka L, Navar LG, Majid DS. High-salt intake enhances superoxide activity in eNOS knockout mice leading to the development of salt sensitivity. Am J Physiol Renal Physiol. 2010 299(3):F656-63

Terms in the title (5)： サイクリックGMP ,  シグナル ,  食塩感受性 ,  可逆性 ,  治療応用