Art

J-GLOBAL ID：202002283903028087   Reference number：20A0108879

Somatic inflammatory gene mutations in human ulcerative colitis epithelium

ヒト潰瘍性大腸炎の上皮における炎症遺伝子の体細胞変異

Author (33)： NANKI Kosaku (Dep. of Organoid Medicine, Keio Univ. School of Medicine, Tokyo, JPN) ,  FUJII Masayuki (Dep. of Organoid Medicine, Keio Univ. School of Medicine, Tokyo, JPN) ,  SHIMOKAWA Mariko (Dep. of Organoid Medicine, Keio Univ. School of Medicine, Tokyo, JPN) ,  MATANO Mami (Dep. of Organoid Medicine, Keio Univ. School of Medicine, Tokyo, JPN) ,  NISHIKORI Shingo (Dep. of Organoid Medicine, Keio Univ. School of Medicine, Tokyo, JPN) ,  DATE Shoichi (Dep. of Organoid Medicine, Keio Univ. School of Medicine, Tokyo, JPN) ,  TAKANO Ai (Dep. of Organoid Medicine, Keio Univ. School of Medicine, Tokyo, JPN) ,  TOSHIMITSU Kohta (Dep. of Organoid Medicine, Keio Univ. School of Medicine, Tokyo, JPN) ,  OHTA Yuki (Dep. of Organoid Medicine, Keio Univ. School of Medicine, Tokyo, JPN) ,  TAKAHASHI Sirirat (Dep. of Organoid Medicine, Keio Univ. School of Medicine, Tokyo, JPN) ,  SUGIMOTO Shinya (Dep. of Organoid Medicine, Keio Univ. School of Medicine, Tokyo, JPN) ,  ISHIMARU Kazuhiro (Dep. of Organoid Medicine, Keio Univ. School of Medicine, Tokyo, JPN) ,  KAWASAKI Kenta (Dep. of Organoid Medicine, Keio Univ. School of Medicine, Tokyo, JPN) ,  YOSHIDA Kosuke (Dep. of Organoid Medicine, Keio Univ. School of Medicine, Tokyo, JPN) ,  SASAKI Nobuo (Dep. of Organoid Medicine, Keio Univ. School of Medicine, Tokyo, JPN) ,  SATO Toshiro (Dep. of Organoid Medicine, Keio Univ. School of Medicine, Tokyo, JPN) ,  NANKI Kosaku (Dep. of Gastroenterology, Keio Univ. School of Medicine, Tokyo, JPN) ,  TOSHIMITSU Kohta (Dep. of Gastroenterology, Keio Univ. School of Medicine, Tokyo, JPN) ,  SUGIMOTO Shinya (Dep. of Gastroenterology, Keio Univ. School of Medicine, Tokyo, JPN) ,  KAWASAKI Kenta (Dep. of Gastroenterology, Keio Univ. School of Medicine, Tokyo, JPN) ,  YOSHIDA Kosuke (Dep. of Gastroenterology, Keio Univ. School of Medicine, Tokyo, JPN) ,  SASAKI Nobuo (Dep. of Gastroenterology, Keio Univ. School of Medicine, Tokyo, JPN) ,  HIBI Toshifumi (Dep. of Gastroenterology, Keio Univ. School of Medicine, Tokyo, JPN) ,  KANAI Takanori (Dep. of Gastroenterology, Keio Univ. School of Medicine, Tokyo, JPN) ,  SATO Toshiro (Dep. of Gastroenterology, Keio Univ. School of Medicine, Tokyo, JPN) ,  FUJII Masayuki (Dep. of Surgical Oncology, Univ. Tokyo, Tokyo, JPN) ,  ISHIMARU Kazuhiro (Dep. of Surgical Oncology, Univ. Tokyo, Tokyo, JPN) ,  ISHIHARA Soichiro (Dep. of Surgical Oncology, Univ. Tokyo, Tokyo, JPN) ,  NISHIKORI Shingo (Fujii Memorial Res. Inst., Otsuka Pharmaceutical Co., Shiga, JPN) ,  DATE Shoichi (Fujii Memorial Res. Inst., Otsuka Pharmaceutical Co., Shiga, JPN) ,  NAGAI Yoko (Fujii Memorial Res. Inst., Otsuka Pharmaceutical Co., Shiga, JPN) ,  ISHII Ryota (Biostatistics Unit, Clinical and Translational Res. Center, Keio Univ. Hospital, Tokyo, JPN) ,  HIBI Toshifumi (Center for Advanced IBD Res. and Treatment, Kitasato Inst. Hospital, Tokyo, JPN)
Material： Nature (London)  (Nature (Lond))
Volume： 577  Issue： 7789  Page： 254-259  Publication year： Jan. 09, 2020 
JST Material Number： D0193B  ISSN： 0028-0836  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： pathogenesis ,  *heredity ,  cellular signal transduction ,  nucleotide sequence ,  clone ,  *gene ,  *inflammation ,  *human(primates) ,  *ulcerative colitis ,  *epithelium ,  apoptosis ,  *large intestine ,  colorectal neoplasm
Semi thesaurus term： インターロイキン17 ,  オルガノイド , 【Automatic Indexing@JST】

JST classification (2)： Genetic variation  (EC01030Y) ,  Carcinogenic mechanisms and factors  (GE02020C)

Terms in the title (6)： ヒト ,  潰瘍性大腸炎 ,  上皮 ,  炎症 ,  遺伝子 ,  体細胞変異