Art

J-GLOBAL ID：202002286557643477   Reference number：20A1416922

Pentabromobenzyl-RP versus triazole-HILIC columns for separation of the polar basic analytes famotidine and famotidone: LC method development combined with in silico tools to follow the potential consequences of famotidine gastric instability

極性塩基性検体ファモチジンとファモチドンの分離用のペンタブロモベンジル-RP対トリアゾール-HILICカラム:ファモチジン胃不安定性の潜在的結果を追跡するためのin silicoツールと組み合わせたLC法開発【JST・京大機械翻訳】

Author (7)： El-Shaheny Rania (Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt) ,  El-Shaheny Rania (Department of Hygienic Chemistry, Graduate School of Biomedical Sciences, Nagasaki University, 1-14 Bunkyo-machi, Nagasaki, 852-8521, Japan) ,  Radwan Mohamed O. (Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, 5e1 Oehonmachi, Chuo-ku, Kumamoto, 862-0973, Japan) ,  Radwan Mohamed O. (Department of Drug Discovery, Science Farm Ltd., 1-7-30 Kuhonji, Chuo-ku, Kumamoto, 862-0976, Japan) ,  Radwan Mohamed O. (Chemistry of Natural Compounds Department, Pharmaceutical and Drug Industries Research Division, National Research Centre, Dokki, 12622, Cairo, Egypt) ,  Belal Fathalla (Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt) ,  Yamada Koji (Medicinal Plant Laboratory, Graduate School of Biomedical Sciences, Nagasaki University, 1-14 Bunkyo-machi, Nagasaki, 852-8521, Japan)
Material： Journal of Pharmaceutical and Biomedical Analysis  (J Pharm Biomed Anal)
Volume： 186  Page： Null  Publication year： 2020 
JST Material Number： H0876A  ISSN： 0731-7085  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： The competence of hydrophilic ...

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Thesaurus term： interaction ,  Chromatography ,  silicon dioxide ,  Gastric Juice ,  receptor ,  pH dependence ,  stationary phase ,  acidity (property) ,  bioavailability ,  detection limit ,  *basicity (property) ,  *in silico ,  decomposition pathway ,  reversed-phase liquid chromatography ,  sulfide (organic) ,  nitrogen heterocyclic compound ,  sulfamide ,  sulfur heterocyclic compound

Author keywords (6)： Famotidine ,  Famotidone ,  RPLC ,  HILIC ,  Gastric instability ,  In silico tools

JST classification (4)： Chromatography and electrophoretic analysis of organic compounds  (CC04034H) ,  Chromatography,electrophoresis  (CC01050S) ,  Liquid chromatography  (CC04014L) ,  Analysis of drugs  (GV01040Q)

Substance index (1)： Famotidine

Terms in the title (13)： 極性 ,  塩基性 ,  検体 ,  ファモチジン ,  RP ,  トリアゾール ,  HILIC ,  カラム ,  胃 ,  不安定性 ,  追跡 ,  ツール ,  開発