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J-GLOBAL ID：202002286885337008   Reference number：20A2760654

Metabolomics analysis elucidates unique influences on purine / pyrimidine metabolism by xanthine oxidoreductase inhibitors in a rat model of renal ischemia-reperfusion injury

メタボロミクス解析は腎虚血-再潅流傷害のラットモデルにおけるキサンチンオキシドレダクターゼ阻害剤によるプリン/ピリミジン代謝への独特な影響を明らかにする【JST・京大機械翻訳】

Author (6)： Tani Takashi (Department of Nephrology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan) ,  Tani Takashi (Department of Metabolism and Nutrition, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan) ,  Okamoto Ken (Department of Metabolism and Nutrition, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan) ,  Fujiwara Megumi (Department of Metabolism and Nutrition, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan) ,  Katayama Akira (Department of Metabolism and Nutrition, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan) ,  Tsuruoka Shuichi (Department of Nephrology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan)
Material： Molecular Medicine (Web)
Volume： 25  Issue： 1  Page： 1-13  Publication year： 2019 
JST Material Number： U7338A  ISSN： 1528-3658  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Abstract/Point： Clinically applied as anti-gou...

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Thesaurus term： enzyme ,  phosphate ,  dissimilation ,  tissue concentration ,  filler(pharmaceuticals) ,  *rat ,  salvage ,  *reperfusion ,  nitrogen heterocyclic compound ,  hydroxy compound ,  enzyme inhibitor
Semi thesaurus term： *メタボロミクス ,  *キサンチンオキシドレダクターゼ , 【Automatic Indexing@JST】

Author keywords (3)： Metabolome ,  Xanthine oxidoreductase inhibitor ,  Ischemia-reperfusion injury

JST classification (2)： Basic research of enzyme preparations and enzyme inhibitor preparations  (GW21010W) ,  Clinical application of other drugs acting on metabolism  (GW13070T)

Substance index (5)： Hypoxanthine ,  Allopurinol ,  Pyrimidine ,  Adenine ,  Purine

Reference (46)：

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Terms in the title (11)： メタボロミクス ,  解析 ,  腎虚血 ,  再潅流傷害 ,  ラット ,  モデル ,  キサンチンオキシドレダクターゼ ,  阻害剤 ,  プリン ,  ピリミジン ,  代謝