Art

J-GLOBAL ID：202002286981285221   Reference number：20A1627983

The PDK1-FoxO1 signaling in adipocytes controls systemic insulin sensitivity through the 5-lipoxygenase-leukotriene B₄ axis

脂肪細胞におけるPDK1-FoxO1シグナル伝達は5-リポキシゲナーゼ-ロイコトリエンB_4軸を介して全身インシュリン感受性を制御する【JST・京大機械翻訳】

Author (26)： Hosooka Tetsuya (Division of Diabetes and Endocrinology, Kobe University Graduate School of Medicine, 650-0017 Kobe, Japan) ,  Hosokawa Yusei (Division of Diabetes and Endocrinology, Kobe University Graduate School of Medicine, 650-0017 Kobe, Japan) ,  Matsugi Kaku (Division of Diabetes and Endocrinology, Kobe University Graduate School of Medicine, 650-0017 Kobe, Japan) ,  Shinohara Masakazu (Division of Epidemiology, Kobe University Graduate School of Medicine, 650-0017 Kobe, Japan) ,  Shinohara Masakazu (The Integrated Center for Mass Spectrometry, Kobe University Graduate School of Medicine, 650-0017 Kobe, Japan) ,  Senga Yoko (Division of Diabetes and Endocrinology, Kobe University Graduate School of Medicine, 650-0017 Kobe, Japan) ,  Tamori Yoshikazu (Division of Diabetes and Endocrinology, Kobe University Graduate School of Medicine, 650-0017 Kobe, Japan) ,  Tamori Yoshikazu (Department of Internal Medicine, Chibune General Hospital, 555-0001 Osaka, Japan) ,  Aoki Chikako (Division of Diabetes and Endocrinology, Kobe University Graduate School of Medicine, 650-0017 Kobe, Japan) ,  Matsui Sho (Metabolic Signal Research Center, Institute for Molecular and Cellular Regulation, Gunma University, 371-8512 Maebashi, Japan) ,  Sasaki Tsutomu (Metabolic Signal Research Center, Institute for Molecular and Cellular Regulation, Gunma University, 371-8512 Maebashi, Japan) ,  Kitamura Tadahiro (Metabolic Signal Research Center, Institute for Molecular and Cellular Regulation, Gunma University, 371-8512 Maebashi, Japan) ,  Kuroda Masashi (Department of Nutrition and Metabolism, Institute of Biomedical Sciences, Tokushima University Graduate School, 770-8503 Tokushima, Japan) ,  Sakaue Hiroshi (Department of Nutrition and Metabolism, Institute of Biomedical Sciences, Tokushima University Graduate School, 770-8503 Tokushima, Japan) ,  Nomura Kazuhiro (Division of Diabetes and Endocrinology, Kobe University Graduate School of Medicine, 650-0017 Kobe, Japan) ,  Yoshino Kei (Division of Diabetes and Endocrinology, Kobe University Graduate School of Medicine, 650-0017 Kobe, Japan) ,  Nabatame Yuko (Division of Diabetes and Endocrinology, Kobe University Graduate School of Medicine, 650-0017 Kobe, Japan) ,  Itoh Yoshito (Department of Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, 602-8566 Kyoto, Japan) ,  Yamaguchi Kanji (Department of Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, 602-8566 Kyoto, Japan) ,  Hayashi Yoshitake (Division of Molecular Medicine and Medical Genetics, Kobe University Graduate School of Medicine, 650-0017 Kobe, Japan) ,  Nakae Jun (Department of Internal Medicine, Keio University School of Medicine, 160-8582 Tokyo, Japan) ,  Accili Domenico (Department of Medicine and Naomi Berrie Diabetes Center, Columbia University, NY 10032) ,  Yokomizo Takehiko (Department of Biochemistry, Juntendo University School of Medicine, 113-8421 Tokyo, Japan) ,  Seino Susumu (Division of Molecular and Metabolic Medicine, Kobe University Graduate School of Medicine, 650-0017 Kobe, Japan) ,  Kasuga Masato (The Institute for Adult Diseases, Asahi Life Foundation, 103-0002 Tokyo, Japan) ,  Ogawa Wataru (Division of Diabetes and Endocrinology, Kobe University Graduate School of Medicine, 650-0017 Kobe, Japan)
Material： Proceedings of the National Academy of Sciences of the United States of America  (PNAS)
Volume： 117  Issue： 21  Page： 11674-11684  Publication year： 2020 
JST Material Number： D0387A  ISSN： 0027-8424  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： Although adipocytes are major ...

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Thesaurus term： plasma(blood) ,  *insulin ,  fatty liver ,  *fat cell ,  adipose tissue ,  phenotype ,  homeostasis ,  *lipoxygenase ,  *cellular signal transduction ,  down-regulation ,  insulin resistance ,  adiponectin ,  leptin
Semi thesaurus term： 炎症マーカー ,  *インスリン感受性 , 【Automatic Indexing@JST】

Author keywords (5)： insulin resistance ,  leukotriene B4 ,  5-lipoxygenase ,  PDK1 ,  FoxO1

JST classification (3)： Metabolic diseases,nutritional diseases in general.  (GD05010J) ,  Enzyme physiology  (EJ02020P) ,  Gene expression  (EC02040Q)

Terms in the title (7)： 脂肪細胞 ,  PDK1 ,  FoxO1 ,  シグナル伝達 ,  5-リポキシゲナーゼ ,  全身 ,  インシュリン感受性