Art

J-GLOBAL ID：202002287270673021   Reference number：20A2067745

Soft Matrix Promotes Cardiac Reprogramming via Inhibition of YAP/TAZ and Suppression of Fibroblast Signatures

ソフトマトリックスはYAP/TAZの阻害と線維芽細胞シグネチャの抑制を介して心臓再プログラミングを促進する【JST・京大機械翻訳】

Author (18)： Kurotsu Shota (Department of Cardiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan) ,  Sadahiro Taketaro (Department of Cardiology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba City, Ibaraki 305-8575, Japan) ,  Fujita Ryo (Department of Cardiology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba City, Ibaraki 305-8575, Japan) ,  Fujita Ryo (Division of Regenerative Medicine, Transborder Medical Research Center, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba City, Ibaraki 305-8575, Japan) ,  Tani Hidenori (Department of Cardiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan) ,  Yamakawa Hiroyuki (Department of Cardiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan) ,  Tamura Fumiya (Department of Cardiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan) ,  Isomi Mari (Department of Cardiology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba City, Ibaraki 305-8575, Japan) ,  Kojima Hidenori (Department of Cardiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan) ,  Yamada Yu (Department of Cardiology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba City, Ibaraki 305-8575, Japan) ,  Abe Yuto (Department of Cardiology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba City, Ibaraki 305-8575, Japan) ,  Murakata Yoshiko (Department of Cardiology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba City, Ibaraki 305-8575, Japan) ,  Akiyama Tatsuya (Department of Respiratory Medicine, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba City, Ibaraki 305-8575, Japan) ,  Muraoka Naoto (Department of Cardiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan) ,  Harada Ichiro (Medical Products Technology Development Center, R&D Headquarters, Canon Inc., 3-30-2 Shimomaruko, Ohta-ku, Tokyo 146-8501, Japan) ,  Suzuki Takeshi (Division of Basic Biological Sciences, Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo 105-8512, Japan) ,  Fukuda Keiichi (Department of Cardiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan) ,  Ieda Masaki (Department of Cardiology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba City, Ibaraki 305-8575, Japan)
Material： Stem Cell Reports
Volume： 15  Issue： 3  Page： 612-628  Publication year： 2020 
JST Material Number： W3132A  ISSN： 2213-6711  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Direct cardiac reprogramming h...

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Thesaurus term： polystyrene ,  rigidity ,  *heart ,  substrate(biochemistry) ,  myocardium ,  *fibroblast ,  hydrogel ,  cellular signal transduction ,  in vitro experiment ,  integrin ,  regenerative medicine ,  cardiac myocyte
Semi thesaurus term： 機械刺激細胞情報伝達 ,  マトリゲル ,  *リプログラミング , 【Automatic Indexing@JST】

Author keywords (5)： soft matrix ,  YAP/TAZ ,  cardiac reprogramming ,  mechanotransduction ,  myocardium

JST classification (2)： Cell physiology in general  (EF02010S) ,  Basic medicine on cardiovascular system  (GJ01020K)

Terms in the title (10)： ソフト ,  マトリックス ,  YAP ,  TAZ ,  阻害 ,  線維芽細胞 ,  シグネチャ ,  心臓 ,  再プログラミング ,  促進