Art

J-GLOBAL ID：202002287713474728   Reference number：20A2435388

Elucidation of Degradation Behavior of Tricyclic Antidepressant Amoxapine in Artificial Gastric Juice

人工胃液における三環系抗うつ薬アモキサピンの分解挙動の解明

Author (6)： Saito Koichi (Department of Analytical Chemistry, Faculty of Pharmaceutical Sciences, Hoshi University) ,  Hagiwara Nami (Department of Analytical Chemistry, Faculty of Pharmaceutical Sciences, Hoshi University) ,  Sakamoto Miho (Department of Pharmaceutical Sciences, Tokyo Metropolitan Institute of Public Health) ,  Wakana Daigo (Department of Bioregulatory Science, Faculty of Pharmaceutical Sciences, Hoshi University) ,  Ito Rie (Department of Analytical Chemistry, Faculty of Pharmaceutical Sciences, Hoshi University) ,  Hosoe Tomoo (Department of Bioregulatory Science, Faculty of Pharmaceutical Sciences, Hoshi University)
Material： Chemical and Pharmaceutical Bulletin (Web)
Volume： 68  Issue： 9  Page： 848-854(J-STAGE)  Publication year： 2020 
JST Material Number： U1401A  ISSN： 1347-5223  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： gastric juice ,...
Semi thesaurus term： time of flight mass spectrometry ,...

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Author keywords (10)： tricyclic antidepressant ,  amoxapine ,  degradation pathway ,  artificial gastric juice ,  HPLC ,  tricyclic antidepressant ,  amoxapine ,  degradation pathway ,  artificial gastric juice ,  HPLC

JST classification (2)： Analysis of drugs  (GV01040Q) ,  Basic research of psychotropic drugs  (GW03100Y)

Substance index (10)： 2-(2-Aminophenoxy)-5-chlorophenyl(piperazino)methanone ,  2-Chlorodibenz[b,f][1,4]oxazepin-11(10H)-one ,  Amitriptyline ,  Amoxapine ,  Imipramine ,  Chlorimipramine ,  Desipramine ,  Doxepin ,  Dosulepin ,  Nortriptyline

Reference (16)：

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• 4) Kudo K., Inoue H., Ishida T., Tsuji A., Ikeda N., Leg. Med., 9, 63-67 (2007).
• 5) Cooper T. B., Kelly R. G., J. Pharm. Sci., 68, 216-219 (1979).

Terms in the title (5)： 人工胃液 ,  三環系抗うつ薬 ,  アモキサピン ,  分解 ,  挙動