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J-GLOBAL ID：202002289082110939   Reference number：20A2491818

Effect of the Conformation of Poly(L-lactide-co-glycolide) Molecules in Organic Solvents on Nanoparticle Size

ナノ粒子径に及ぼす有機溶媒中のポリ(L-ラクチドーco-グリコリド)分子の立体配座の影響

Author (5)： Takeuchi Issei (Faculty of Pharmaceutical Sciences, Tokyo University of Science) ,  Takeuchi Issei (Center for Drug Delivery Research, Tokyo University of Science) ,  Kimura Yukie (Faculty of Pharmaceutical Sciences, Tokyo University of Science) ,  Makino Kimiko (Faculty of Pharmaceutical Sciences, Tokyo University of Science) ,  Makino Kimiko (Center for Drug Delivery Research, Tokyo University of Science)
Material： Journal of Oleo Science  (J Oleo Sci)
Volume： 69  Issue： 9  Page： 1125-1132(J-STAGE)  Publication year： 2020 
JST Material Number： G0238A  ISSN： 1345-8957  CODEN： JOSOAP  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *poly(lactic-glycolic acid) ,...
Semi thesaurus term： SEM (microscope) ,...

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Author keywords (5)： poly(L-lactide-co-glycolide) ,  nanoparticle ,  organic solvent ,  intrinsic viscosity ,  polymer coil

JST classification (2)： Physical pharmacy  (GY01012A) ,  Physicochemical characteristics of drugs  (GV01060M)

Substance index (4)： 1-Propanol ,  Ethanol ,  Methylene chloride ,  Methanol

Reference (29)：

• 1) Prausnitz, M.R.; Langer, R. Transdermal drug delivery. Nature Biotech. 26, 1261-1268 (2008).
• 2) Köhler, D. Aerosols for systemic treatment. Lung 168, 677-684 (1990).
• 3) Nii, T.; Takeuchi, I.; Kimura, Y.; Makino, K. Effects of the conformation of PLGA molecules in the organic solvent on the aerodynamic diameter of spray dried microparticles. Colloids. Surf. A 539, 347-353 (2018).
• 4) Takeuchi, I.; Koshi, Y.; Makino, K. Drug delivery properties of nanocomposite particles for inhalation: Comparison of drug concentrations in lungs and blood. In Vivo 34, 543-547 (2020).
• 5) Ungaro, F.; Angelo, L.; Miro, A.; La Rotonda, M.I.; Quaglia, F. Engineered PLGA nano- and micro-carriers for pulmonary delivery: Challenges and promises. J. Pharm. Pharmacol. 64 1217-1235 (2012).

Terms in the title (5)： 粒子径 ,  有機溶媒 ,  グリコリド ,  分子 ,  立体配座