Art

J-GLOBAL ID：202002289623186315   Reference number：20A1762474

Oxidative Formation of Methylglyoxal in Glycerol Preparations during Storage

貯蔵中のグリセロール製剤におけるメチルグリオキサールの酸化物生成

Author (4)： Sugiura Ko (Department of Analytical Biochemistry, Meiji Pharmaceutical University) ,  Koike Shin (Department of Analytical Biochemistry, Meiji Pharmaceutical University) ,  Suzuki Toshihiro (Department of Analytical Biochemistry, Meiji Pharmaceutical University) ,  Ogasawara Yuki (Department of Analytical Biochemistry, Meiji Pharmaceutical University)
Material： Biological and Pharmaceutical Bulletin (Web)
Volume： 43  Issue： 5  Page： 879-883(J-STAGE)  Publication year： 2020 
JST Material Number： U1402A  ISSN： 1347-5215  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： human ,...
Semi thesaurus term： *グリセロール製剤 ,...

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Author keywords (10)： methylglyoxal ,  glycerol preparation ,  stability ,  oxidation ,  carbonyl stress ,  methylglyoxal ,  glycerol preparation ,  stability ,  oxidation ,  carbonyl stress

JST classification (1)： Physicochemical pharmacy in general  (GV01010J)

Substance index (2)： Glycerol ,  Methylglyoxal

Reference (19)：

• 1) Kalapos MP. Methylglyoxal in living organisms: chemistry, biochemistry, toxicology and biological implications. Toxicol. Lett., 110, 145-175 (1999).
• 2) Migliore L, Barale R, Bosco E, Giorgelli F, Minunni M, Scarpato R, Loprieno N. Genotoxicity of methylglyoxal: cytogenetic damage in human lymphocytes in vitro and in intestinal cells of mice. Carcinogenesis, 11, 1503-1507 (1990).
• 3) Hanssen NM, Stehouwer CD, Schalkwijk CG. Methylglyoxal and glyoxalase I in atherosclerosis. Biochem. Soc. Trans., 42, 443-449 (2014).
• 4) Rabbani N, Thornalley PJ. Advanced glycation end products in the pathogenesis of chronic kidney disease. Kidney Int., 93, 803-813 (2018).
• 5) Angeloni C, Zambonin L, Hrelia S. Role of methylglyoxal in Alzheimer’s disease. Biomed. Res. Int., 2014, 238485 (2014).

Terms in the title (5)： 貯蔵 ,  グリセロール ,  製剤 ,  メチルグリオキサール ,  酸化物