Art

J-GLOBAL ID：202002289866978224   Reference number：20A2034314

Acetylation-dependent regulation of PD-L1 nuclear translocation dictates the efficacy of anti-PD-1 immunotherapy

PD-L1核転座のアセチル化依存性調節は抗PD-1免疫療法の有効性を決定する【JST・京大機械翻訳】

Author (37)： Gao Yang (Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA) ,  Gao Yang (Department of Urology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China) ,  Nihira Naoe Taira (Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA) ,  Nihira Naoe Taira (Department of Molecular Genetics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan) ,  Nihira Naoe Taira (Division of Pediatric Dentistry, Department of Oral Health and Development Sciences, Tohoku University Graduate School of Dentistry, Sendai, Japan) ,  Bu Xia (Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA) ,  Chu Chen (Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA) ,  Chu Chen (Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA) ,  Zhang Jinfang (Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA) ,  Kolodziejczyk Aleksandra (Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA) ,  Kolodziejczyk Aleksandra (Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA) ,  Fan Yizeng (Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA) ,  Fan Yizeng (Department of Urology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China) ,  Chan Ngai Ting (McArdle Laboratory for Cancer Research, University of Wisconsin-Madison, Madison, WI, USA) ,  Ma Leina (Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA) ,  Liu Jing (Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA) ,  Wang Dong (Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA) ,  Dai Xiaoming (Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA) ,  Liu Huadong (Center for Mitochondrial Biology and Medicine, The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology and Frontier Institute of Science and Technology, Xi’an Jiaotong University, Xi’ an, China) ,  Ono Masaya (Department of Clinical Proteomics, National Cancer Center Research Institute, Tokyo, Japan) ,  Nakanishi Akira (Department of Molecular Genetics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan) ,  Inuzuka Hiroyuki (Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA) ,  North Brian J. (Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA) ,  Huang Yu-Han (Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA) ,  Huang Yu-Han (Division of Genetics and Genomics, Boston Children’s Hospital, Boston, MA, USA) ,  Sharma Samanta (Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA) ,  Sharma Samanta (Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA) ,  Geng Yan (Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA) ,  Geng Yan (Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA) ,  Xu Wei (McArdle Laboratory for Cancer Research, University of Wisconsin-Madison, Madison, WI, USA) ,  Liu X. Shirley (Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA, USA) ,  Li Lei (Department of Urology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China) ,  Miki Yoshio (Department of Molecular Genetics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan) ,  Sicinski Piotr (Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA) ,  Sicinski Piotr (Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA) ,  Freeman Gordon J. (Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA) ,  Wei Wenyi (Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA)
Material： Nature Cell Biology  (Nat Cell Biol)
Volume： 22  Issue： 9  Page： 1064-1075  Publication year： 2020 
JST Material Number： W1369A  ISSN： 1465-7392  Document type： Article
Article type： 原著論文  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Abstract/Point： Abstract: Immunotherapies that...

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Thesaurus term： interaction ,  *acetylation ,  heredity ,  gene ,  cell nucleus ,  cell membrane ,  tumor ,  protein ,  immunological reaction ,  *immunotherapy ,  endocytosis ,  *translocation(genetics) ,  gene expression ,  targeting
Semi thesaurus term： p300 , 【Automatic Indexing@JST】

JST classification (2)： Biological function  (EB03040U) ,  Cell physiology in general  (EF02010S)

Terms in the title (9)： PD-L1 ,  核 ,  転座 ,  アセチル化 ,  依存性 ,  調節 ,  PD-1 ,  免疫療法 ,  有効性