Art

J-GLOBAL ID：202002291090039758   Reference number：20A2711850

Selective Targeting of Cancerous Mitochondria and Suppression of Tumor Growth Using Redox-Active Treatment Adjuvant

レドックス活性治療アジュバントを用いた癌ミトコンドリアの選択的標的化と腫瘍増殖の抑制【JST・京大機械翻訳】

Author (17)： Bakalova Rumiana (Quantum-State Controlled MRI Group, Institute for Quantum Life Science, National Institutes for Quantum and Radiological Science and Technology (QST), 4-9-1 Anagawa, Chiba 263-8555, Japan) ,  Bakalova Rumiana (Functional and Molecular Imaging Team, Department of Molecular Imaging and Theranostics, National Institute of Radiological Sciences (NIRS), QST, 4-9-1 Anagawa, Chiba 263-8555, Japan) ,  Bakalova Rumiana (Medical Faculty, Sofia University, 1 Koziak Str., Sofia 1407, Bulgaria) ,  Semkova Severina (Quantum-State Controlled MRI Group, Institute for Quantum Life Science, National Institutes for Quantum and Radiological Science and Technology (QST), 4-9-1 Anagawa, Chiba 263-8555, Japan) ,  Semkova Severina (Functional and Molecular Imaging Team, Department of Molecular Imaging and Theranostics, National Institute of Radiological Sciences (NIRS), QST, 4-9-1 Anagawa, Chiba 263-8555, Japan) ,  Semkova Severina (Institute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, 21 Acad. G. Bonchev Str., Sofia 1113, Bulgaria) ,  Ivanova Donika (Faculty of Veterinary Medicine, Trakia University, 11 Armejska Str., Stara Zagora 6000, Bulgaria) ,  Zhelev Zhivko (Institute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, 21 Acad. G. Bonchev Str., Sofia 1113, Bulgaria) ,  Zhelev Zhivko (Medical Faculty, Trakia University, 11 Armejska Str., Stara Zagora 6000, Bulgaria) ,  Miller Thomas (IC-MedTech Co., San Diego, CA, USA) ,  Takeshima Tsuguhide (Radiation and Cancer Biology Group, Department of Charged Particle Therapy Research, National Institute of Radiological Sciences (NIRS), QST, 4-9-1 Anagawa, Chiba 263-8555, Japan) ,  Shibata Sayaka (Quantum-State Controlled MRI Group, Institute for Quantum Life Science, National Institutes for Quantum and Radiological Science and Technology (QST), 4-9-1 Anagawa, Chiba 263-8555, Japan) ,  Shibata Sayaka (Functional and Molecular Imaging Team, Department of Molecular Imaging and Theranostics, National Institute of Radiological Sciences (NIRS), QST, 4-9-1 Anagawa, Chiba 263-8555, Japan) ,  Lazarova Dessislava (Medical Faculty, Sofia University, 1 Koziak Str., Sofia 1407, Bulgaria) ,  Aoki Ichio (Quantum-State Controlled MRI Group, Institute for Quantum Life Science, National Institutes for Quantum and Radiological Science and Technology (QST), 4-9-1 Anagawa, Chiba 263-8555, Japan) ,  Aoki Ichio (Functional and Molecular Imaging Team, Department of Molecular Imaging and Theranostics, National Institute of Radiological Sciences (NIRS), QST, 4-9-1 Anagawa, Chiba 263-8555, Japan) ,  Higashi Tatsuya (Functional and Molecular Imaging Team, Department of Molecular Imaging and Theranostics, National Institute of Radiological Sciences (NIRS), QST, 4-9-1 Anagawa, Chiba 263-8555, Japan)
Material： Oxidative Medicine and Cellular Longevity (Web)  (Oxidative Med Cell Longev (Web))
Volume： 2020  Page： Null  Publication year： 2020 
JST Material Number： U7012A  ISSN： 1942-0900  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Abstract/Point： Redox-active substances and th...

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Thesaurus term： quinone ,  superoxide ,  antitumor action ,  tumor cell ,  *Mitochondria ,  lymphocyte ,  *oxidation-reduction reaction ,  survival ratio ,  cytotoxicity ,  *targeting ,  Apoptosis ,  oxidative stress ,  lactone ,  water-soluble vitamin ,  secondary alcohol ,  polyol ,  alicyclic compound ,  diene ,  polynuclear aromatic compound
Semi thesaurus term： 癌治療 , 【Automatic Indexing@JST】

JST classification (3)： Function of cell components  (EF03060C) ,  Cell physiology in general  (EF02010S) ,  Biological function  (EB03040U)

Substance index (2)： Ascorbic Acid ,  Menadione

Reference (141)：

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• B. Marriage, M. T. Clandinin, D. M. Glerum, "Nutritional cofactor treatment in mitochondrial disorders," Journal of the American Dietetic Association, vol. 103, no. 8, pp. 1029-1038, 2003.
• P. Calderon, J. Verrax, H. Taper, "Targeting cancer cells by an oxidant-based therapy," Current Molecular Pharmacology, vol. 1, no. 1, pp. 80-92, 2008.
• H. S. Taper, "Altered deoxyribonuclease activity in cancer cells and its role in non toxic adjuvant cancer therapy with mixed vitamins C and K3," Anticancer Research, vol. 28, no. 5A, pp. 2727-2732, 2008.
• J. Verrax, R. Pedrosa, R. Beck, N. Dejeans, H. Taper, P. Calderon, "In situ modulation of oxidative stress: a novel and efficient strategy to kill cancer cells," Current Medicinal Chemistry, vol. 16, no. 15, pp. 1821-1830, 2009.

Terms in the title (8)： レドックス ,  活性 ,  治療 ,  アジュバント ,  癌 ,  ミトコンドリア ,  標的化 ,  腫瘍増殖