- 2024 - 2027 関節の恒常性維持と破綻における超硫黄分子の機能解明に基づく関節疾患治療の基盤構築
- 2024 - 2027 The mechanism of joint homeostasis in the coupling of articular cartilage and synovium
- 2023 - 2027 関節の恒常性を司る、滑膜と軟骨の連関制御機構の解明
- 2021 - 2026 The elucidation of joint homeostasis regulated by lubricin/Prg4-expressing cells using next generation sequencing technology
- 2022 - 2024 Development of effective tissue regeneration method based on single cell genomics of neural crest derived cell
- 2021 - 2024 Identification of pathogenesis, and development of therapeutic method for ossification of posterior longitudinal ligament recognized among inherited FGF23-related hypophosphatemic rickets/osteomalacia
- 2020 - 2024 Cdk6による骨格幹細胞G0/G1期制御機構の解明と骨再生医療に向けた基礎的検討
- 2020 - 2024 Cdk6による骨格幹細胞G0/G1期制御機構の解明と骨再生医療に向けた基礎的検討
- 2020 - 2023 Notchシグナルによる関節幹細胞の維持機構の解明
- 2020 - 2023 変形性関節症におけるケモカインシグナル・フロントに着目した新規治療法の開発
- 2020 - 2023 神経根症の発症に関与する細胞群の解析と間葉系幹細胞による病態制御法の開発
- 2020 - 2023 自然免疫細胞と破骨細胞の骨免疫ネットワークの解明
- 2020 - 2023 Notchシグナルによる関節幹細胞の維持機構の解明
- 2020 - 2023 変形性関節症におけるケモカインシグナル・フロントに着目した新規治療法の開発
- 2019 - 2022 Prg4 を標的とした変形性関節症治療薬開発のための基盤研究
- 2018 - 2022 Prg4に立脚した、細胞・分子の多層的アプローチによる関節形成・維持機構の解明
- 2017 - 2020 Elucidation of tendon regeneration mechanism using achilles tendon resection model.
- 2017 - 2020 Wnt/b-catenin signaling contributes to articular cartilage homeostasis through lubricin induction in the superficial zone
- 2017 - 2019 靭帯骨化に関わる細胞集団とシグナル連関の解明
- 2016 - 2019 Basic research for the nanosheet to overcome serious clinical problems in the field of orthopedic surgery
- 2015 - 2018 Molecular Mechanisms of How Mechanical Stress Regulates Inflammation of Locomotive Organs
- 2015 - 2018 Mechanism of maintainace of articular chondrocyte by NF-kB signaling.
- 2015 - 2018 Transcription factor Hes1 modulates osteoarthritis development
- 2015 - 2018 Regulation of articular joint diseases by transcription factor family C/EBP
- 2015 - 2018 Identification of candidate compounds for the maintenance of SFZ in the articular cartilage through Prg4 induction
- 2016 - 2018 Runx1 contributes to articular cartilage maintenance by enhancement of cartilage matrix production and suppression of hypertrophic differentiation(Fostering Joint International Research)
- 2014 - 2017 Development of chondrocyte differentiation method from human iPS cells
- 2013 - 2017 Runx1 contributes to articular cartilage maintenance through enhancement of cartilage matrix production and suppression of hypertrophic differentiation
- 2012 - 2016 Mechanism and its regulation of lipid rafts in the osteoclastic resorption of bone
- 2012 - 2015 a new disease-modifying osteoarthritis drug (DMOAD) candidate using a cell based screening system
- 2011 - 2014 Examination of hybrid bone grafts using nano DDS and artificial bones
- 2010 - 2013 The mechanism of transcriptional factor Runx1 in chondrogenic differentiation
- 2011 - 2013 Elucidation of tendon calcification inhibition mechanism of histamine H2-receptor antagonist
- 2009 - 2012 β-catenin regulates parathyroid hormone/parathyroid hormone-related protein receptor signals and chondrocyte hypertrophy through binding to the intracellular C-terminal region of the receptor.
- 2009 - 2011 The elucidation of the between PTH and COX-2 in bone reconstruction
- 2009 - 2010 顎顔面領域軟骨欠損部に対する新たな軟骨再生法の確立
- 2008 - 2010 Strategic research for the identification of novel osteogenic small compounds and their application to bone regeneration
- 2008 - 2010 Clarification of interaction between β-catenin and PTH in osteogenesis for craniofacial bone regeneration
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