Art

J-GLOBAL ID：202102214410207620   Reference number：21A0470974

Tenofovir-disoproxil-fumarate modulates lipid metabolism via hepatic CD36/PPAR-alpha activation in hepatitis B virus infection

テノホビル-ジソプロキシル-フマル酸はB型肝炎ウイルス感染において肝臓CD36/PPAR-αの活性化を介して脂質代謝を変化させる

Author (24)： Suzuki Kazuharu (Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan) ,  Suda Goki (Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan) ,  Yamamoto Yoshiya (Department of Gastroenterology, Hakodate Municipal Hospital, Hokkaido, Japan) ,  Furuya Ken (Department of Gastroenterology, JCHO Hokkaido Hospital, Hokkaido, Japan) ,  Baba Masaru (Department of Gastroenterology, JCHO Hokkaido Hospital, Hokkaido, Japan) ,  Nakamura Akinobu (Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University Graduate School of Medicine, Hokkaido, Japan) ,  Miyoshi Hideaki (Division of Diabetes and Obesity, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan) ,  Kimura Megumi (Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan) ,  Maehara Osamu (Department of Gastroenterology, Hakodate Municipal Hospital, Hokkaido, Japan) ,  Yamada Ren (Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan) ,  Kitagataya Takashi (Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan) ,  Yamamoto Koji (Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan) ,  Shigesawa Taku (Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan) ,  Nakamura Akihisa (Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan) ,  Ohara Masatsugu (Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan) ,  Kawagishi Naoki (Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan) ,  Nakai Masato (Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan) ,  Sho Takuya (Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan) ,  Natsuizaka Mitsuteru (Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan) ,  Morikawa Kenichi (Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan) ,  Ogawa Koji (Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan) ,  Ohnishi Shunsuke (Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan) ,  Sakamoto Naoya (Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan) ,  for the NORTE Study Group
Material： Journal of Gastroenterology (Web)
Volume： 56  Issue： 2  Page： 168-180  Publication year： 2021 
JST Material Number： U1592A  ISSN： 0944-1174  Document type： Article
Article type： 原著論文  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Thesaurus term： human ,...
Semi thesaurus term： cellular signal transduction ,...

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Author keywords (5)： Hepatitis B virus ,  Lipid metabolism ,  Oxidized LDL ,  CD36 ,  PPAR-alpha

JST classification (4)： Drug therapy(=pharmacotherapy)for digestive system diseases  (GH05020G) ,  Treatment for infectious diseases,parasitic diseases.  (GD01030D) ,  Clinical application of antiviral drugs  (GW17050Z) ,  Poisoning in general  (GD06010Q)

Substance index (1)： Tenofovir disoproxil fumarate

Terms in the title (7)： テノホビル ,  フマル酸 ,  B型肝炎ウイルス感染 ,  肝臓 ,  CD36 ,  活性化 ,  脂質代謝