Art

J-GLOBAL ID：202102220258724335   Reference number：21A0023913

A selective p38α/β MAPK inhibitor alleviates neuropathology and cognitive impairment, and modulates microglia function in 5XFAD mouse

選択的p38α/β MAPK阻害剤は神経病理学と認知障害を軽減し,5XFADマウスにおけるミクログリア機能を調節する【JST・京大機械翻訳】

Author (14)： Gee Min Sung (Department of Fundamental Pharmaceutical Science, Graduate School, Kyung Hee University, Seoul, Republic of Korea) ,  Son Seung Hwan (Department of Fundamental Pharmaceutical Science, Graduate School, Kyung Hee University, Seoul, Republic of Korea) ,  Jeon Seung Ho (Department of Fundamental Pharmaceutical Science, Graduate School, Kyung Hee University, Seoul, Republic of Korea) ,  Do Jimin (Department of Biomedical Science and Technology, Graduate School, Kyung Hee University, Seoul, Republic of Korea) ,  Kim Namkwon (Department of Life and Nanopharmaceutical Sciences, Graduate School, Kyung Hee University, Seoul, Republic of Korea) ,  Ju Yeon-Joo (Department of Fundamental Pharmaceutical Science, Graduate School, Kyung Hee University, Seoul, Republic of Korea) ,  Lee Soo Jin (Department of Fundamental Pharmaceutical Science, Graduate School, Kyung Hee University, Seoul, Republic of Korea) ,  Chung Eun Kyoung (Department of Fundamental Pharmaceutical Science, Graduate School, Kyung Hee University, Seoul, Republic of Korea) ,  Inn Kyung-Soo (Department of Life and Nanopharmaceutical Sciences, Graduate School, Kyung Hee University, Seoul, Republic of Korea) ,  Kim Nam-Jung (Department of Fundamental Pharmaceutical Science, Graduate School, Kyung Hee University, Seoul, Republic of Korea) ,  Kim Nam-Jung (Department of Life and Nanopharmaceutical Sciences, Graduate School, Kyung Hee University, Seoul, Republic of Korea) ,  Kim Nam-Jung (Department of Pharmacy, College of Pharmacy, Kyung Hee University, Seoul, Republic of Korea) ,  Lee Jong Kil (Department of Fundamental Pharmaceutical Science, Graduate School, Kyung Hee University, Seoul, Republic of Korea) ,  Lee Jong Kil (Department of Pharmacy, College of Pharmacy, Kyung Hee University, Seoul, Republic of Korea)
Material： Alzheimer's Research & Therapy (Web)
Volume： 12  Issue： 1  Page： 1-18  Publication year： 2020 
JST Material Number： U7297A  ISSN： 1758-9193  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Abstract/Point： Chronic neuroinflammation, agg...

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Thesaurus term： neuron ,  Inflammation ,  memory disorder ,  cytotoxicity ,  deposition ,  Alzheimer Disease ,  *pathological state ,  in vitro experiment ,  astrocyte ,  TUNEL method ,  p38 MAP kinase ,  *microglia ,  amyloid beta-protein ,  *Cognition Disorders ,  *P38 ,  Amyloid ,  glycoprotein ,  animal protein

Author keywords (5)： Alzheimer’s disease ,  Amyloid-β ,  P38 mitogen-activated protein kinase ,  Kinase inhibitor ,  Microglia

JST classification (2)： Basic neurology  (GN01020W) ,  Basic research of other drugs acting on central nervous system  (GW03120U)

Reference (59)：

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Terms in the title (8)： p38α ,  MAPK ,  阻害剤 ,  神経病理学 ,  認知障害 ,  マウス ,  ミクログリア ,  調節