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J-GLOBAL ID：202102230417264690   Reference number：21A0348845

Phosphorylation-dependent Regnase-1 release from endoplasmic reticulum is critical in IL-17 response

小胞体からのリン酸化依存性レグナーゼ-1放出はIL-17応答に重要である【JST・京大機械翻訳】

Author (13)： Tanaka Hiroki (Laboratory of Host Defense, World Premier Institute Immunology Frontier Research Center, Osaka University, Osaka, Japan) ,  Arima Yasunobu (Division of Molecular Neuroimmunology, Institute for Genetic Medicine, Hokkaido University, Hokkaido, Japan) ,  Kamimura Daisuke (Division of Molecular Neuroimmunology, Institute for Genetic Medicine, Hokkaido University, Hokkaido, Japan) ,  Tanaka Yuki (Division of Molecular Neuroimmunology, Institute for Genetic Medicine, Hokkaido University, Hokkaido, Japan) ,  Takahashi Noriyuki (Kamakura Research Laboratories, Chugai Pharmaceutical Co. Ltd., Kanagawa, Japan) ,  Uehata Takuya (Department of Host Defense, Research Institute for Microbial Research, Osaka University, Osaka, Japan) ,  Maeda Kazuhiko (Laboratory of Host Defense, World Premier Institute Immunology Frontier Research Center, Osaka University, Osaka, Japan) ,  Maeda Kazuhiko (Department of Host Defense, Research Institute for Microbial Research, Osaka University, Osaka, Japan) ,  Satoh Takashi (Laboratory of Host Defense, World Premier Institute Immunology Frontier Research Center, Osaka University, Osaka, Japan) ,  Satoh Takashi (Department of Host Defense, Research Institute for Microbial Research, Osaka University, Osaka, Japan) ,  Murakami Masaaki (Division of Molecular Neuroimmunology, Institute for Genetic Medicine, Hokkaido University, Hokkaido, Japan) ,  Akira Shizuo (Laboratory of Host Defense, World Premier Institute Immunology Frontier Research Center, Osaka University, Osaka, Japan) ,  Akira Shizuo (Department of Host Defense, Research Institute for Microbial Research, Osaka University, Osaka, Japan)
Material： Journal of Experimental Medicine  (J Exp Med)
Volume： 216  Issue： 6  Page： 1431-1449  Publication year： 2019 
JST Material Number： A0937B  ISSN： 0022-1007  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： Regnase-1 (also known as Zc3h1...

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Thesaurus term： gene ,  inflammation ,  *endoplasmic reticulum ,  *phosphorylation ,  cytosol ,  inactivation ,  interleukin ,  post-translational modification
Semi thesaurus term： エンドリボヌクレアーゼ ,  *インターロイキン17 ,  mRNA分解 ,  標的遺伝子 ,  Th17細胞 ,  TANK結合キナーゼ 1 ,  炎症性疾患 , 【Automatic Indexing@JST】

JST classification (2)： Immunological reaction in general  (ED03010T) ,  Gene expression  (EC02040Q)

Reference (48)：

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• Arima. Regional neural activation defines a gateway for autoreactive T cells to cross the blood-brain barrier. Cell. 2012, 148, 447. doi:10.1016/j.cell.2012.01.022
• Beutler. Microbe sensing, positive feedback loops, and the pathogenesis of inflammatory diseases. Immunol. Rev. 2009, 227, 248. doi:10.1111/j.1600-065X.2008.00733.x
• Brook. Posttranslational regulation of tristetraprolin subcellular localization and protein stability by p38 mitogen-activated protein kinase and extracellular signal-regulated kinase pathways. Mol. Cell. Biol. 2006, 26, 2408. doi:10.1128/MCB.26.6.2408-2418.2006

Terms in the title (7)： 小胞体 ,  リン酸化 ,  依存性 ,  レグナーゼ-1 ,  放出 ,  IL-17 ,  応答