Art

J-GLOBAL ID：202102234428067067   Reference number：21A0168373

Development of Novel Diclofenac Analogs Designed to Avoid Metabolic Activation and Hepatocyte Toxicity

代謝活性化と肝細胞毒性を避けるために設計した新規ジクロフェナク類似体の開発【JST・京大機械翻訳】

Author (6)： Tateishi Yasuhiro (Faculty of Pharmacy, Keio University, Japan) ,  Ohe Tomoyuki (Faculty of Pharmacy, Keio University, Japan) ,  Ogawa Mai (Faculty of Pharmacy, Keio University, Japan) ,  Takahashi Kyoko (Faculty of Pharmacy, Keio University, Japan) ,  Nakamura Shigeo (Department of Chemistry, Nippon Medical School, Japan) ,  Mashino Tadahiko (Faculty of Pharmacy, Keio University, Japan)
Material： ACS Omega
Volume： 5  Issue： 50  Page： 32608-32616  Publication year： 2020 
JST Material Number： W5044A  ISSN： 2470-1343  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： Diclofenac (DCF) is widely use...

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Thesaurus term： fluorine ,  Hydrogen ,  enzyme ,  sulfonic acid ,  glucuronic acid conjugation ,  metabolite ,  sulfonamide ,  cytochrome P450 ,  *cytotoxicity ,  cyclooxygenase ,  *hepatocyte ,  inhibitory activity ,  metabolic stability ,  adverse reaction ,  non-steroidal anti-inflammatory drug
Semi thesaurus term： non-steroidal anti-inflammatory agent , 【Automatic Indexing@JST】

JST classification (4)： Basic biopharmacy  (GY01021U) ,  Toxicity of organic compounds  (GZ02030Y) ,  Basic research of anti-inflammatory drugs  (GW15010T) ,  Basic medicine on digestive system  (GH01020E)

Terms in the title (6)： 代謝活性化 ,  細胞毒性 ,  設計 ,  ジクロフェナク ,  類似体 ,  開発