Art

J-GLOBAL ID：202102242685876742   Reference number：21A0468768

L-balenine inhibits the catalytic activity of Pin1, a peptidyl prolyl cis/trans-isomerase

L-バレニンはペプチジルプロリルcis/transイソメラーゼ,Pin1の触媒活性を阻害する

Author (6)： TAKAHASHI Katsuhiko (HOSHI Univ., Tokyo, JPN) ,  TAKAHASHI Katsuhiko (SHOWA Univ. School of Medicine, Tokyo, JPN) ,  UCHIDA Takafumi (TOHOKU Univ., Sendai, JPN) ,  UCHIDA Takafumi (HOSHI Univ., Tokyo, JPN) ,  HIGASHI Nobuaki (HOSHI Univ., Tokyo, JPN) ,  KAMEI Junzo (HOSHI Univ., Tokyo, JPN)
Material： Personalized Medicine Universe (Web)
Volume： 9  Issue： (冊子)  Page： 51-58  Publication year： Nov. 2020 
JST Material Number： W2403B  ISSN： 2186-4950  Document type： Article
Article type： 短報  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： human ,...
Semi thesaurus term： *L-バレニン ,...

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JST classification (3)： Amino acids  (CF10070V) ,  Bioactive peptides  (EB08100U) ,  Basic research of enzyme preparations and enzyme inhibitor preparations  (GW21010W)

Substance index (1)： Balenine

Reference (51)：

• [1] Lu KP, Hanes SD, Hunter T. A human peptidyl-prolyl isomerase essential for regulation of mitosis. Nature 1996; 380: 544-7. doi: 10.1038/380544a0.
• [2] Takahashi K, Uchida C, Shin RW, et al. Prolyl isomerase, Pin1: new findings of post-translational modifications and physiological substrates in cancer, asthma and Alzheimer's disease. Cell Mol Life Sci 2008; 65: 359-75. doi: 10.1007/s00018-007-7270-0.
• [3] Zhou XZ, Lu KP. The isomerase PIN1 controls numerous cancer-driving pathwaysand is a unique drug target. Nat Rev Cancer 2016; 16: 463-78. doi: 10.1038/nrc.2016.49.
• [4] Pu W, Zheng Y, Peng Y. Prolyl Isomerase Pin1 in Human Cancer: Function, Mechanism, and Significance. Front Cell Dev Biol 2020; 8: 168. doi: 10.3389/fcell.2020.00168.
• [5] Bao L, Kimzey A, Sauter G, et al. Prevalent overexpression of prolyl isomerase Pin1 in human cancers. Am J Pathol 2004; 164: 1727-37. doi: 10.1016/S0002-9440 (10) 63731-5.

Terms in the title (6)： バレニン ,  CIS ,  イソメラーゼ ,  Pin1 ,  触媒活性 ,  阻害