Art

J-GLOBAL ID：202102249985438418   Reference number：21A0194437

Discovery of a multipotent chaperone, 1-(2,6-Difluorobenzylamino)-3-(1,2,3,4-tetrahydrocarbazol-9-yl)-propan-2-ol with the inhibitory effects on the proliferation of prion, cancer as well as influenza virus

インフルエンザウイルスと同様のプリオン,癌の増殖に対する阻害作用を有する多能性シャペロン,1-(2,6-ジフルオロベンジルアミノ)-3-(1,2,3,4-テトラヒドロカルバゾール-9-イル)-プロパン-2-オールの発見【JST・京大機械翻訳】

Author (7)： Yamashita Satoshi (United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, Gifu, Japan) ,  Honda Ryo (United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, Gifu, Japan) ,  Fukuoka Mayuko (United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, Gifu, Japan) ,  Kimura Tsutomu (Department of Chemistry, Faculty of Science Division II, Tokyo University of Science, Tokyo, Japan) ,  Hosokawa-Muto Junji (First Department of Forsenic Science, National Research Institute of Police Science, Chiba, Japan) ,  Kuwata Kazuo (United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, Gifu, Japan) ,  Kuwata Kazuo (Department of Gene and Development, Graduate School of Medicine, Gifu University, Gifu, Japan)
Material： Prion
Volume： 14  Issue： 1  Page： 42-46  Publication year： 2020 
JST Material Number： W6030A  ISSN： 1933-6896  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Abstract/Point： ABSTRACT: We previously discov...

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Thesaurus term： optimization ,  *influenza virus ,  antitumor action ,  spectrum ,  amino acid residue ,  targeting ,  Scrapie ,  colonic neoplasm ,  *chaperone protein ,  *Prions ,  *prion protein ,  lead compound ,  Antiprion Action ,  modification ,  *microorganism ,  *Proteins ,  *glycoprotein ,  nitrogen heterocyclic compound ,  polynuclear aromatic compound
Semi thesaurus term： 抗プリオン活性 , 【Automatic Indexing@JST】

Author keywords (10)： Chaperone ,  multipotent ,  stabilization ,  free energy ,  activation free energy ,  prion ,  cancer ,  influenza virus ,  anti-viral agent ,  carbazol

JST classification (3)： Basic research of drugs acting on other pathogenic organisms  (GW17100F) ,  Biological function  (EB03040U) ,  Central nervous system  (EJ12030F)

Substance index (1)： Carbazole

Terms in the title (9)： インフルエンザウイルス ,  プリオン ,  癌 ,  増殖 ,  阻害作用 ,  多能性 ,  シャペロン ,  プロパン-2-オール ,  発見