Art

J-GLOBAL ID：202102250071710484   Reference number：21A0328377

Effects of acid and lactone forms of statins on S-warfarin 7-hydroxylation catalyzed by human liver microsomes and recombinant CYP2C9 variants (CYP2C9.1 and CYP2C9.3)

ヒト肝ミクロソームおよび組換CYP2C9変異体(CYP2C9.1およびCYP2C9.3)により触媒されるS-ワルファリン7-ヒドロキシル化に及ぼすスタチン類の酸およびラクトン型の影響

Author (7)： Shiozawa Ayaka (Department of Pharmacy, Shinshu University Hospital, 3-1-1 Asahi, Matsumoto, 390-8621, Japan) ,  Shiozawa Ayaka (Department of Biochemical Pharmacology and Toxicology, Graduate School of Medicine, Shinshu University, 3-1-1 Asahi, Matsumoto, 390-8621, Japan) ,  Yamaori Satoshi (Department of Pharmacy, Shinshu University Hospital, 3-1-1 Asahi, Matsumoto, 390-8621, Japan) ,  Yamaori Satoshi (Department of Biochemical Pharmacology and Toxicology, Graduate School of Medicine, Shinshu University, 3-1-1 Asahi, Matsumoto, 390-8621, Japan) ,  Kamijo Shinobu (Department of Biochemical Pharmacology and Toxicology, Graduate School of Medicine, Shinshu University, 3-1-1 Asahi, Matsumoto, 390-8621, Japan) ,  Ohmori Shigeru (Department of Pharmacy, Shinshu University Hospital, 3-1-1 Asahi, Matsumoto, 390-8621, Japan) ,  Ohmori Shigeru (Department of Biochemical Pharmacology and Toxicology, Graduate School of Medicine, Shinshu University, 3-1-1 Asahi, Matsumoto, 390-8621, Japan)
Material： Drug Metabolism and Pharmacokinetics (Web)  (Drug Metab Pharmacokinet (Web))
Volume： 36  Page： Null  Publication year： 2021 
JST Material Number： U0705A  ISSN： 1347-4367  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： *cytochrome P450 ,...
Semi thesaurus term： recombination ,...

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Author keywords (5)： Statin ,  Warfarin ,  CYP2C9 ,  Inhibition ,  Polymorphism

JST classification (2)： Basic biopharmacy  (GY01021U) ,  Basic research of drugs acting on lipid metabolism  (GW13040M)

Substance index (7)： Atorvastatin ,  Lovastatin ,  Pitavastatin ,  Pravastatin ,  Rosuvastatin ,  Simvastatin ,  Warfarin

Terms in the title (10)： ヒト肝ミクロソーム ,  組換 ,  CYP2C9 ,  変異体 ,  触媒 ,  S-ワルファリン ,  ヒドロキシル化 ,  スタチン類 ,  酸 ,  ラクトン