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J-GLOBAL ID：202102261955872946   Reference number：21A0031581

Chemical Synthesis of an Erythropoietin Glycoform Having a Triantennary N-Glycan: Significant Change of Biological Activity of Glycoprotein by Addition of a Small Molecular Weight Trisaccharide

トリアンテナN-グリカンを有するエリスロポイエチン糖型の化学合成:低分子量三糖類の添加による糖蛋白質の生物活性の顕著な変化【JST・京大機械翻訳】

Author (7)： Maki Yuta (Department of Chemistry, Graduate School of Science, Osaka University, Japan) ,  Maki Yuta (Project Research Center for Fundamental Sciences, Graduate School of Science, Japan) ,  Okamoto Ryo (Department of Chemistry, Graduate School of Science, Osaka University, Japan) ,  Okamoto Ryo (Project Research Center for Fundamental Sciences, Graduate School of Science, Japan) ,  Izumi Masayuki (Department of Chemistry, Graduate School of Science, Osaka University, Japan) ,  Kajihara Yasuhiro (Department of Chemistry, Graduate School of Science, Osaka University, Japan) ,  Kajihara Yasuhiro (Project Research Center for Fundamental Sciences, Graduate School of Science, Japan)
Material： Journal of the American Chemical Society  (J Am Chem Soc)
Volume： 142  Issue： 49  Page： 20671-20679  Publication year： 2020 
JST Material Number： C0254A  ISSN： 0002-7863  CODEN： JACSAT  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： The glycosylation of proteins ...

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Thesaurus term： *antenna (electric) ,  *erythropoietin ,  antenna (animal) ,  *Proteins ,  *glycoprotein ,  liquid phase ,  hemopoiesis ,  *chemical synthesis ,  *biological activity ,  *trisaccharide ,  Glycosylation ,  *low molecular weight ,  *N-glycan ,  protein function ,  partial chemical synthesis ,  phase (thermodynamics)
Semi thesaurus term： 半合成 , 【Automatic Indexing@JST】

JST classification (1)： Carbohydrates and sugar chains in general  (EB06010I)

Terms in the title (9)： トリ ,  アンテナ ,  N-グリカン ,  エリスロポイエチン ,  化学合成 ,  低分子量 ,  糖類 ,  糖蛋白質 ,  生物活性