Art

J-GLOBAL ID：202102266179235939   Reference number：21A0079170

Fullerene derivatives as dual inhibitors of HIV-1 reverse transcriptase and protease

HIV-1逆転写酵素とプロテアーゼの二重阻害剤としてのフラーレン誘導体【JST・京大機械翻訳】

Author (11)： Yasuno Takumi (Department of Pharmaceutical Sciences, Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo, Japan) ,  Ohe Tomoyuki (Department of Pharmaceutical Sciences, Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo, Japan) ,  Kataoka Hiroki (Department of Pharmaceutical Sciences, Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo, Japan) ,  Hashimoto Kosho (Department of Pharmaceutical Sciences, Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo, Japan) ,  Ishikawa Yumiko (Department of Pharmaceutical Sciences, Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo, Japan) ,  Furukawa Keigo (Department of Pharmaceutical Sciences, Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo, Japan) ,  Tateishi Yasuhiro (Department of Pharmaceutical Sciences, Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo, Japan) ,  Kobayashi Toi (Department of Pharmaceutical Sciences, Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo, Japan) ,  Takahashi Kyoko (Department of Pharmaceutical Sciences, Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo, Japan) ,  Nakamura Shigeo (Department of Chemistry, Nippon Medical School, 1-7-1 Kyonan-cho, Musashino-shi, Tokyo, Japan) ,  Mashino Tadahiko (Department of Pharmaceutical Sciences, Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo, Japan)
Material： Bioorganic & Medicinal Chemistry Letters  (Bioorg Med Chem Lett)
Volume： 31  Page： Null  Publication year： 2021 
JST Material Number： W0248A  ISSN： 0960-894X  Document type： Article
Article type： 短報  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： In the present study, we newly...

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Thesaurus term： *peptide bond hydrolase ,  alkyl group ,  *HIV ,  *fullerene ,  inhibitory activity ,  *microorganism ,  *animal virus ,  nitrogen heterocyclic compound ,  amino acid

Author keywords (3)： Fullerene ,  HIV reverse transcriptase ,  HIV protease

JST classification (2)： Basic research of antiviral drugs  (GW17040O) ,  Basic research of enzyme preparations and enzyme inhibitor preparations  (GW21010W)

Substance index (2)： Pyrrolidine ,  Proline

Terms in the title (4)： HIV-1逆転写酵素 ,  プロテアーゼ ,  阻害剤 ,  フラーレン誘導体